Thomas Südhof

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Thomas Christian Südhof (born December 22, 1955 in Göttingen ) is a German-American biochemist who works in neuroscience on research into synapses , the fundamental switching points of the nervous system. He is a professor at Stanford University and heads the Südhof Laboratory there at the Medical School. In 2013 he was awarded the Nobel Prize in Physiology or Medicine together with James Rothman and Randy Schekman .

Thomas Südhof 2013

Live and act

Südhof grew up in Göttingen and Hanover. After graduating from the Waldorf School in Hanover in 1975 , Südhof studied medicine at RWTH Aachen University , Harvard University and Göttingen University . In 1982, he was with a dissertation on the structure and function of the chromaffin cells in which the adrenal hormones epinephrine and norepinephrine are formed at the Max Planck Institute for Biophysical Chemistry under Victor P. Whittaker to Dr. med. PhD. The dissertation was entitled The biophysical structure of chromaffin granules in the light of their osmometer behavior and their osmotic lysis . In 1983, Südhof went to the Department of Molecular Genetics at the University of Texas Southwestern Medical Center (UT Southwestern) in Dallas as a postdoc under the direction of the later Nobel Prize winners Michael Stuart Brown and Joseph L. Goldstein . There he succeeded in cloning the LDL receptor. He then turned to research into the molecular basis of signal transmission in the nervous system and in 1991 became a professor in the Faculty of Molecular Genetics at UT Southwestern. In particular, he researched the mechanism by which neurotransmitters are released at synapses. He succeeded in identifying and cloning a number of the proteins involved. Between 1995 and 1998, Südhof was a "Scientific Member" of the Max Planck Society and director at the Max Planck Institute for Experimental Medicine in Göttingen. He then returned to Dallas, Texas.

One of his areas of research is the question of how synapses are formed in the embryonic development of the brain and later during learning processes ( synaptic plasticity ) and how they are specified. Südhof also conducts research into the causes of neuronal diseases such as Alzheimer's , Parkinson's disease , schizophrenia , anxiety and autism, and into the effects of botulin on a cellular and molecular basis.

In 2008, Südhof moved to Stanford University , where he is Professor of Molecular and Cellular Physiology , Psychiatry and Neurology at the Faculty of Medicine .

In October 2013, Südhof received the Nobel Prize in Physiology or Medicine together with James Rothman and Randy Schekman, because they "through their discoveries uncovered the highly precise control system for the transport and delivery of cellular cargo" ("Through their discoveries, Rothman, Schekman and Südhof have revealed the exquisitely precise control system for the transport and delivery of cellular cargo ").

At the beginning of 2014, the Berlin Institute for Health Research (BIG) appointed Südhof as a visiting fellow. This makes him the first scientist to be brought to Berlin with funds from the private excellence initiative Johanna Quandt, administered by the Charité Foundation . In autumn 2014 he will start his work in Berlin and, with Christian Rosenmund from Charité - Universitätsmedizin Berlin and spokesman for the Neurocure Cluster of Excellence, set up a project that deals with the question of how nerve cells in the brain communicate with one another.

He has US citizenship and, since 2013, German citizenship again.

Private

According to its own information, Südhof has seven children from two marriages.

Prizes and awards

Fonts (selection)

  • TC Südhof: The structure of the human synapsin I gene and protein. In: Journal of Biological Chemistry. Volume 265, 1990, pp. 7849-7852.
  • N. Brose, AG Petrenko, TC Südhof and Jahn, R .: Synaptotagmin: A Ca2 + sensor on the synaptic vesicle surface. In: Science . Volume 256, 1992, pp. 1021-1025.
  • YA Ushkaryov, AG Petrenko, M. Geppert and TC Südhof: Neurexins: Synaptic cell surface proteins related to the α-latrotoxin receptor and laminin. In: Science. Volume 257, 1992, pp. 50-56.
  • M. Geppert, VY Bolshakov, SA Siegelbaum, K. Takei, P. De Camilli, RE Hammer and TC Südhof: The role of Rab3A in neurotransmitter release. In: Nature . Volume 369, 1994, pp. 493-497.
  • M. Geppert, Y. Goda, RE Hammer, C. Li, TW Rosahl, CF Stevens and TC Südhof: Synaptotagmin I: A major Ca2 + sensor for transmitter release at a central synapse. In: Cell. Volume 79, 1994, pp. 717-727.
  • S. Schoch, PE Castillo, T. Jo, K. Mukherjee, M. Geppert, Y. Wang, F. Schmitz, RC Malenka and TC Südhof: RIM1α forms a protein scaffold for regulating neurotransmitter release at the active zone. In: Nature. Volume 415, 2002, pp. 321-326.
  • TC Südhof: Calcium control of neurotransmitter release. In: Cold Spring Harbor Perspectives in Biology . Volume 4, No. 1, 2012

Web links

Individual evidence

  1. ^ Nobel laureate Thomas Südhof: "I would like to come back to Germany". In: Der Spiegel. October 8, 2013, accessed October 8, 2013 .
  2. ↑ Südhoff Lab. Stanford Medicine, accessed May 7, 2017 .
  3. ^ Nobelprize.org: The Nobel Prize in Physiology or Medicine 2013 , accessed October 7, 2013
  4. ↑ Nobel Prize for Medicine goes to Germans. In: Mitteldeutsche Zeitung , October 7, 2013.
  5. ^ TC Südhof, JL Goldstein, MS Brown and DW Russell: The LDL receptor gene: A mosaic of exons shared with different proteins. In: Science . Volume 228, 1985, pp. 815-822, PMC 4450672 (free full text).
  6. ↑ PTS Ma, G. Gil, TC Südhof, DW Bilheimer, JL Goldstein and MS Brown: Mevinolin, an inhibitor of cholesterol synthesis, induces mRNA for low density lipoprotein receptor in livers of hamsters and rabbits. In: Proc. Natl. Acad. Sci. USA . Volume 83, 1986, pp. 8370-8374, PMC 386930 (free full text).
  7. ↑ PA Dawson, SL Hofmann, DR Van Der Westhuyzen, TC Südhof, MS Brown and JL Goldstein: Sterol-dependent repression of low density lipoprotein receptor promoter mediated by 16-base pair sequence adjacent to binding site for transcription factor SP1. In: J. Biol. Chem. Volume 263, 1988, pp. 3372-3379, PMID 3277969 (free full text).
  8. ↑ Chronicle of the KWG / MPG 1911–2011. ISBN 978-3-428-13623-0 , p. 993, see also Sudhof autobiography
  9. ↑ CM Powell, S. Schoch, L. Monteggia, M. Barrot, MF Matos, TC Südhof and EJ Nestler: The Presynaptic Active Zone Protein RIM1α is Critical for Normal Associative Learning. In: Neuron. Volume 42, 2004, pp. 143-153; TW Rosahl, M. Geppert, D. Spillane, J. Herz, RE Hammer, RC Malenka and TC Südhof: Short term synaptic plasticity is altered in mice lacking synapsin I. In: Cell . Volume 75, 1993, pp. 661-670.
  10. ↑ I. Dulubova, A. Ho, TC Südhof and J. Rizo: Three-Dimensional Structure of an Independently Folded Extracellular Domain of Human Amyloid-β Precursor Protein. In: Biochemistry . Volume 43, 2004, pp. 9583-9588; A. Ho, X. Liu and TC Südhof: Deletion of Mint proteins decreases amyloid production in transgenic mouse models of Alzheimer's disease. In: J. Neurosci. Volume 28, 2008, pp. 14392-14400.
  11. ↑ OM Schlüter, F. Fornai, MG Alessandri, p Takamori, M. Geppert, R. Jahn and TC Südhof: Role of α-synuclein in MPTP-induced Parkinsonism in Mice. In: Neuroscience. Volume 118, 2003, pp. 985-1002
  12. Jump up ↑ J. Blundell, K. Tabuchi, MF Bolliger, CA Blaiss, N. Brose, X. Liu, TC Südhof and CM Powell: Increased Anxiety-like Behavior in Mice Lacking the Inhibitory Synapse Cell Adhesion Molecule Neuroligin 2. In: Genes Brain Behav. Volume 8, No. 1, February 2009, pp. 114-126. Epub November 11, 2008.
  13. ↑ AA Chubykin, X. Liu, D. Comoletti, I. Tsigelny, P. Taylor and TC Südhof: Dissection of Synapse Induction by Neuroligins: Effect of a Neuroligin Mutation Associated with Autism. In: J. Biol. Chem. Volume 280, 2005, pp. 22365-22374; K. Tabuchi, J. Blundell, MR Etherton, RE Hammer, X. Liu, CM Powell and TC Südhof: A Neuroligin-3 Mutation Implicated in Autism Increases Inhibitory Synaptic Transmission in Mice. In: Science. Volume 318, 2007, pp. 71-76.
  14. ↑ J. Blasi, ER Chapman, E. Link, T. Binz, S. Yamasaki, P. De Camilli, TC Südhof, H. Niemann and R. Jahn: Botulinum neurotoxin A selectively cleaves the synaptic protein SNAP-25. In: Nature . Volume 365, 1993, pp. 160-163.
  15. ^ Stanford Report: Report of the President to the Board of Trustees Published April 9, 2008. Accessed August 15, 2014.
  16. ^ Medical Nobel Prize winner Südhof is doing research in Germany again. Federal Ministry of Education and Research press release Press release 015/2014 of February 27, 2014, accessed on February 28, 2014
  17. ↑ "I have a German passport again". In: Berliner Zeitung. March 10, 2014.
  18. ↑ Interview in the FAZ of October 4, 2015, p. 25
  19. ↑ Member entry by Prof. Dr. Thomas C. Südhof (with picture and CV) at the German Academy of Natural Scientists Leopoldina , accessed on June 11, 2016.
personal data
SURNAME Südhof, Thomas
ALTERNATIVE NAMES Südhof, Thomas C .; Südhof, Thomas Christian (full name)
BRIEF DESCRIPTION German-American biochemist and Nobel Prize winner for medicine
DATE OF BIRTH December 22, 1955
PLACE OF BIRTH Goettingen