Hypoxia-induced factor
Hypoxia-induced factor 1, α-subunit | ||
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according to PDB 1H2K | ||
Existing structural data : 1d7g , 1h2k , 1h2l , 1h2m , 1l3e , 1l8c , 1lm8 , 1lq8 , 2ilm , 4ZPR |
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Properties of human protein | ||
Mass / length primary structure | 826 amino acids; 92.7 kDa | |
Isoforms | 2 | |
Identifier | ||
Gene names | HIF1A ; HIF-1alpha; HIF1-ALPHA; MOP1; PASD8 | |
External IDs | ||
Occurrence | ||
Parent taxon | Chordates | |
Orthologue | ||
human | mouse | |
Entrez | 3091 | 15251 |
Ensemble | ENSG00000100644 | ENSMUSG00000021109 |
UniProt | Q16665 | Q61221 |
Refseq (mRNA) | NM_001530 | NM_010431 |
Refseq (protein) | NP_001521 | NP_034561 |
Gene locus | Chr 14: 61.23 - 61.28 Mb | Chr 12: 75 - 75.05 Mb |
PubMed search | 3091 |
15251
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Hypoxia-inducible factors ( HIF ) is a transcription factor , which supply the cell with oxygen regulated by establishing a balance between the oxygen demand and oxygen supply. HIF consists of a labile α-subunit that exists in three isoforms , HIF-1α, HIF-2α and HIF-3α, and a β-subunit.
With normal oxygen supply (normoxia) the α-subunit is hydroxylated on two specific prolyl residues . This hydroxylation leads to HIFα being broken down by the Von Hippel Lindau tumor suppressor protein (pVHL).
When there is insufficient oxygen supply ( hypoxia ), the hydroxylation of HIF-α is inhibited. The thus stabilized transcription factor activates the erythropoietin - gene and a number of other genes which for adapting the cell to a lack of supply of oxygen are required. Furthermore, various experiments indicate HIF-induced expression of growth factors of the group Vascular Endothelial Growth Factor (VEGF).
Individual evidence
- ↑ KM Mohamed, A. Le u. a .: Correlation between VEGF and HIF-1alpha expression in human oral squamous cell carcinoma. In: Experimental and molecular pathology Volume 76, Number 2, April 2004, pp 143-152. doi : 10.1016 / j.yexmp.2003.10.005 . PMID 15010293 .
- ↑ D. Shweiki, A. Itin et al. a .: Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. In: Nature Volume 359, Number 6398, October 1992, pp. 843-845. doi : 10.1038 / 359843a0 . PMID 1279431 .
literature
- Percy, Melanie J. et al .: A Gain-of-Function Mutation in the HIF2A Gene in Familial Erythrocytosis . In: N Engl J Med . No. 358 , 2008, p. 162-168 ( abstract ).
- Frontiers in Nephrology: Thomas O. Daniel et al .: Integrating Renal Hypoxic Signals in Development and Disease . In: J Am Soc Nephrol . No. 14 , 2003, p. 2693-2694 ( Article ). - Series of overview articles on the fundamentals and medical significance of the oxygen sensor system.