Mikulicz syndrome

Classification according to ICD-10
K11.8	'Other diseases of the salivary glands'
ICD-10 online (WHO version 2019)

The Mikulicz syndrome (after Johann Freiherr von Mikulicz-Radecki , 1892) describes a reactive swelling of the tear and salivary glands in various general and systemic diseases. The disease is also known as Dacryo-sialo-adenopathia atrophicans , Mikulicz-Radecki syndrome or Mikulicz-Sjogren's syndrome .

etiology

Mikulicz syndrome occurs with Hodgkin and non-Hodgkin lymphomas , chronic lymphocytic leukemia, and sarcoid . It is also occasionally observed in tuberculosis , syphilis , sialadenosis, and hyperthyroidism . The exact cause of Mikulicz syndrome is unknown, but it is believed to be an autoimmune disease .

Symptoms

Mikulicz's syndrome is characterized by the sudden onset of extreme dryness of the mouth (xerostomia), which is accompanied by difficulty swallowing and promotes the development of tooth decay , as the natural teeth cleaning by the saliva is missing. Further symptoms are enlarged lacrimal glands with reduced tear production, an enlargement of the parotid gland (glandula parotis), hard, painless swellings of the salivary glands . Symptoms may persist for a long time or may appear periodically and then go away. The symptoms of Mikulicz syndrome are very similar to Sjogren's syndrome . Some researchers suspect that they are identical disorders.

diagnosis

A biopsy of one of the swollen glands can be done to confirm the diagnosis . An ultrasound scan of the glands can help identify other reasons for the swelling of the glands.

Differential diagnosis

therapy

Therapy is carried out by treating the underlying disease. Otherwise, this disease is treated symptomatically . Artificial tears can be used to help maintain moisture in the eyes. Oral symptoms can be alleviated using artificial saliva.

Web links

Sjogren's Syndrome: A guide for the patient . Retrieved October 3, 2014

Individual evidence

↑ KJ Awan: Mikulicz's disease and Mikulicz's syndrome. In: Southern medical journal. Volume 69, Number 4, April 1976, pp. 458-462, ISSN 0038-4348 . PMID 1265507 .
↑ JG Azzopardi, DJ Evans: Malignant lymphoma of parotid associated with Mikulicz disease (benign lymphoepithelial lesion). In: Journal of clinical pathology. Volume 24, Number 8, November 1971, pp. 744-752, ISSN 0021-9746 . PMID 4943296 . PMC 477147 (free full text).
↑ K. Tsubota, H. Fujita et al. a .: Mikulicz's disease and Sjogren's syndrome. In: Investigative ophthalmology & visual science. Volume 41, Number 7, June 2000, pp. 1666-1673, ISSN 0146-0404 . PMID 10845583 .
^ CN Penfold: Mikulicz syndrome. In: Journal of oral and maxillofacial surgery: official journal of the American Association of Oral and Maxillofacial Surgeons. Volume 43, Number 11, November 1985, pp. 900-905, ISSN 0278-2391 . PMID 3903084 .

[PMID1265507-1] KJ Awan: Mikulicz's disease and Mikulicz's syndrome. In: Southern medical journal. Volume 69, Number 4, April 1976, pp. 458-462, ISSN 0038-4348 . PMID 1265507 .

[PMID4943296-2] JG Azzopardi, DJ Evans: Malignant lymphoma of parotid associated with Mikulicz disease (benign lymphoepithelial lesion). In: Journal of clinical pathology. Volume 24, Number 8, November 1971, pp. 744-752, ISSN 0021-9746 . PMID 4943296 . PMC 477147 (free full text).

[PMID10845583-3] K. Tsubota, H. Fujita et al. a .: Mikulicz's disease and Sjogren's syndrome. In: Investigative ophthalmology & visual science. Volume 41, Number 7, June 2000, pp. 1666-1673, ISSN 0146-0404 . PMID 10845583 .

[PMID3903084-4] CN Penfold: Mikulicz syndrome. In: Journal of oral and maxillofacial surgery: official journal of the American Association of Oral and Maxillofacial Surgeons. Volume 43, Number 11, November 1985, pp. 900-905, ISSN 0278-2391 . PMID 3903084 .