Miroslav Radman

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Miroslav Radman (born April 30, 1944 in Split ) is a Croatian-French molecular biologist , known for his contributions to the study of DNA repair .

Life

Radman studied biology and physical chemistry at the University of Zagreb from 1962, graduating in 1967 and received his doctorate in molecular biology at the Free University of Brussels in 1969 . He was a post-graduate student at Harvard University . From 1973 he was Professor of Molecular Biology at the Free University of Brussels and from 1983 to 1997 Research Director of the CNRS at the Jacques Monod Institute at the University of Paris VII . He then became Professor of Cell Biology at the University of Paris V (René Descartes).

He is co-founder of the Mediterranean Institute of Life Sciences (MedILS) in Split.

He was involved in four start-ups in France and the USA and holds seven patents. Around 190 scientific papers come from him. He is the initiator and co-founder of EITP (European Institute of Technology in Paris).

plant

He is considered to be the discoverer of the SOS response . The hypothesis that the cell carries out such a general stop of gene expression in the event of severe damage to the DNA, he had already in 1970 (published 1974)

He also showed how DNA base mismatch repair of the cell in bacteria prevents recombination with similar chromosomes and thus builds up species barriers.

He also researched the repair of severe DNA damage in Deinococcus radiodurans . This bacterium can survive extreme dehydration and ionizing radiation with a special DNA repair mechanism (extended synthesis-dependent strand annealing, EDSA).

The SOS mechanism also plays a role in antibiotic resistance, which Radman also researched.

Honors and memberships

In 1992 he received the Léopold Griffuel Prize and in 2003 the INSERM Grand Prix. In 2011 he received the Lwoff Award from the Federation of European Microbiological Societies and in 1992 the Prix ​​Charles-Léopold Mayer .

He became a full member of the Academie des Sciences in 2002, the American Academy of Arts and Sciences in 2015, and the National Academy of Sciences in 2018 . He has been a corresponding member of the Croatian Academy of Sciences and Arts since 1991 and a full member of the Academia Europaea since 1999 . He is a Knight of the Legion of Honor . He is a member of the EMBO .

Fonts

  • Au-delà de nos limites biologiques, Plon 2011

Web links

Individual evidence

  1. ↑ Radman, Phenomenology of an inducible mutagenic DNA repair pathway in Escherichia coli: SOS repair hypothesis, in: L. Prakash, F. Sherman, M. Miller, C. Lawrence, HW Tabor (eds.), Molecular and Environmental Aspects of Mutagenesis , Charles C Thomas, Springfield, III., Vol. 6, 1974, pp. 128-142.
  2. ↑ Radman, Phenomenology of an inducible mutagenic DNA repair pathway in Escherichia coli: SOS repair pichulein hypothesis, Basic Life Sciences, Volume 5A, 1974, pp 355-367
  3. ↑ C. Rayssiguier, DS Thales, M. Radman: The barrier to recombination between Escherichia coli and Salmonella typhimurium is disrupted in mismatch repair mutants, Nature, Vol 342, 1989, pp 396-401
  4. ↑ Radman et al. a .: Reassembly of shattered chromosomes in Deinococcus radiodurans, Nature, Volume 443, 2006, pp. 569-573, PMID 17006450
personal data
SURNAME Radman, Miroslav
BRIEF DESCRIPTION Croatian-French molecular biologist
DATE OF BIRTH April 30, 1944
PLACE OF BIRTH Split