Motilin

Motilin
	Ribbon / rod model according to PDB 1LBJ
Properties of human protein
Mass / length primary structure	22 amino acids
Precursor	PhD (115 AS)
Identifier
Gene name	MLN
External IDs	OMIM : 158270 ; UniProt : P12872 ;
Occurrence
Homology family	Motilin precursor
Parent taxon	Eutheria

Motilin is a gastrointestinal peptide hormone that is produced in the M cells of the small intestine (the number of which decreases from duodenum to ileum ) and is released together with ghrelin . The peptide consists of 22 amino acids .

function

By docking to the motilin receptor (in the mucosa , myenteric plexus , small intestine - muscles , Purkinje cells ), motilin triggers interdigestive motility in the stomach and intestines . In a Chinese study, gallstone patients had elevated blood motilin levels. Motilin may play a role in the body's response to acupuncture . Nothing is known about its function in Purkinje cells.

regulation

Stimulus for secretion: high fat meals, stomach distension, bile and pH drop in the duodenum . The control of the secretion is also done neuronally and by serotonin .

Certain antibiotics (macrolides) act as agonists on the motilin receptor and thus trigger gastrointestinal disorders.

Individual evidence

↑ UniProt P12872
↑ Wierup N, Björkqvist M, Weström B, Pierzynowski S, Sundler F, Sjölund K: Ghrelin and motilin are cosecreted from a prominent endocrine cell population in the small intestine . In: J. Clin. Endocrinol. Metab. . 92, No. 9, September 2007, pp. 3573-81. doi : 10.1210 / jc.2006-2756 . PMID 17595255 .
↑ Zhang ZH, Wu SD, Su Y, et al : Differences and significance of motilin, vasoactive intestinal peptide and gastrin in blood and gallbladder tissues of patients with gallstones . In: HBPD INT . 7, No. 1, February 2008, pp. 58-64. PMID 18234640 .
↑ Poitras P, Peeters TL: Motilin . In: Curr Opin Endocrinol Diabetes Obes . 15, No. 1, February 2008, pp. 54-7. doi : 10.1097 / MED.0b013e3282f370af . PMID 18185063 .
↑ Niu WX, He GD, Liu H, Qin XY: Effects and probable mechanisms of electroacupuncture at the Zusanli point on upper gastrointestinal motility in rabbits . In: J Gastroenterol Hepatol . 22, No. 10, October 2007, pp. 1683-9. doi : 10.1111 / j.1440-1746.2007.05049.x . PMID 17645478 .
↑ Chen H, Chen L, Wang JJ, Wei HJ, Yung WH: Distribution and electrophysiological effects of motilin in Purkinje cells . In: Neuroreport . 18, No. 13, August 2007, pp. 1345-9. doi : 10.1097 / WNR.0b013e328273bc98 . PMID 17762710 .

[1] UniProt P12872

[2] Wierup N, Björkqvist M, Weström B, Pierzynowski S, Sundler F, Sjölund K: Ghrelin and motilin are cosecreted from a prominent endocrine cell population in the small intestine . In: J. Clin. Endocrinol. Metab. . 92, No. 9, September 2007, pp. 3573-81. doi : 10.1210 / jc.2006-2756 . PMID 17595255 .

[3] Zhang ZH, Wu SD, Su Y, et al : Differences and significance of motilin, vasoactive intestinal peptide and gastrin in blood and gallbladder tissues of patients with gallstones . In: HBPD INT . 7, No. 1, February 2008, pp. 58-64. PMID 18234640 .

[4] Poitras P, Peeters TL: Motilin . In: Curr Opin Endocrinol Diabetes Obes . 15, No. 1, February 2008, pp. 54-7. doi : 10.1097 / MED.0b013e3282f370af . PMID 18185063 .

[5] Niu WX, He GD, Liu H, Qin XY: Effects and probable mechanisms of electroacupuncture at the Zusanli point on upper gastrointestinal motility in rabbits . In: J Gastroenterol Hepatol . 22, No. 10, October 2007, pp. 1683-9. doi : 10.1111 / j.1440-1746.2007.05049.x . PMID 17645478 .

[6] Chen H, Chen L, Wang JJ, Wei HJ, Yung WH: Distribution and electrophysiological effects of motilin in Purkinje cells . In: Neuroreport . 18, No. 13, August 2007, pp. 1345-9. doi : 10.1097 / WNR.0b013e328273bc98 . PMID 17762710 .