Motilin
Motilin | ||
---|---|---|
Ribbon / rod model according to PDB 1LBJ | ||
Properties of human protein | ||
Mass / length primary structure | 22 amino acids | |
Precursor | PhD (115 AS) | |
Identifier | ||
Gene name | MLN | |
External IDs | ||
Occurrence | ||
Homology family | Motilin precursor | |
Parent taxon | Eutheria |
Motilin is a gastrointestinal peptide hormone that is produced in the M cells of the small intestine (the number of which decreases from duodenum to ileum ) and is released together with ghrelin . The peptide consists of 22 amino acids .
function
By docking to the motilin receptor (in the mucosa , myenteric plexus , small intestine - muscles , Purkinje cells ), motilin triggers interdigestive motility in the stomach and intestines . In a Chinese study, gallstone patients had elevated blood motilin levels. Motilin may play a role in the body's response to acupuncture . Nothing is known about its function in Purkinje cells.
regulation
Stimulus for secretion: high fat meals, stomach distension, bile and pH drop in the duodenum . The control of the secretion is also done neuronally and by serotonin .
Certain antibiotics (macrolides) act as agonists on the motilin receptor and thus trigger gastrointestinal disorders.
Individual evidence
- ↑ UniProt P12872
- ↑ Wierup N, Björkqvist M, Weström B, Pierzynowski S, Sundler F, Sjölund K: Ghrelin and motilin are cosecreted from a prominent endocrine cell population in the small intestine . In: J. Clin. Endocrinol. Metab. . 92, No. 9, September 2007, pp. 3573-81. doi : 10.1210 / jc.2006-2756 . PMID 17595255 .
- ↑ Zhang ZH, Wu SD, Su Y, et al : Differences and significance of motilin, vasoactive intestinal peptide and gastrin in blood and gallbladder tissues of patients with gallstones . In: HBPD INT . 7, No. 1, February 2008, pp. 58-64. PMID 18234640 .
- ↑ Poitras P, Peeters TL: Motilin . In: Curr Opin Endocrinol Diabetes Obes . 15, No. 1, February 2008, pp. 54-7. doi : 10.1097 / MED.0b013e3282f370af . PMID 18185063 .
- ↑ Niu WX, He GD, Liu H, Qin XY: Effects and probable mechanisms of electroacupuncture at the Zusanli point on upper gastrointestinal motility in rabbits . In: J Gastroenterol Hepatol . 22, No. 10, October 2007, pp. 1683-9. doi : 10.1111 / j.1440-1746.2007.05049.x . PMID 17645478 .
- ↑ Chen H, Chen L, Wang JJ, Wei HJ, Yung WH: Distribution and electrophysiological effects of motilin in Purkinje cells . In: Neuroreport . 18, No. 13, August 2007, pp. 1345-9. doi : 10.1097 / WNR.0b013e328273bc98 . PMID 17762710 .