Non-structural protein 2 (influenza virus A)

non-structural protein 2
	Existing structural data : 1PD3
Mass / length primary structure	121 amino acids , 14.4 kDa
Identifier
External IDs	UniProt : P03508 ;

The non-structural protein 2 (NS2, synonym nuclear export protein , NEP) of the influenza virus is a protein that during an infection in the course of an immune evasion the immune response decreases and increases the production of Tochtervirionen.

properties

The non-structural protein 2, like the non-structural protein 1 , mostly does not occur in the virion , which is where the name comes from. NS2 is occasionally found in small amounts in the virion, but is predominantly in the cytosol and the cell nucleus . NS2 has a nuclear export signal, binds to matrix protein 1 and mediates the export of newly formed viral ribonucleoproteins from the cell nucleus into the cytosol via CRM1 . The NS2 gene lies on the same genomic segment as the NS1 gene . NS2 also regulates the replication and transcription of the RNA of influenza viruses.

Individual evidence

↑ ^a ^b D. M. Knipe, Peter M. Howley (Ed.): Fields Virology . 4th edition, Philadelphia 2001, ISBN 0-7817-6060-7 .
^ Y. Hu, X. Liu, A. Zhang, H. Zhou, Z. Liu, H. Chen, M. Jin: CHD3 facilitates vRNP nuclear export by interacting with NES1 of influenza A virus NS2. In: Cellular and molecular life sciences: CMLS. [Electronic publication before printing] September 2014, ISSN 1420-9071 , doi : 10.1007 / s00018-014-1726-9 , PMID 25213355 .
↑ K. Watanabe, T. Shimizu, S. Noda, F. Tsukahara, Y. Maru, N. Kobayashi: Nuclear export of the influenza virus ribonucleoprotein complex: Interaction of Hsc70 with viral proteins M1 and NS2. In: FEBS open bio. Volume 4, 2014, ISSN 2211-5463 , pp. 683-688, doi : 10.1016 / j.fob.2014.07.004 , PMID 25161876 , PMC 4141210 (free full text).
^ D. Paterson, E. Fodor: Emerging roles for the influenza A virus nuclear export protein (NEP). In: PLoS pathogens. Volume 8, number 12, 2012, ISSN 1553-7374 , p. E1003019, doi : 10.1371 / journal.ppat.1003019 , PMID 23236273 , PMC 3516560 (free full text).

[Fields-1] D. M. Knipe, Peter M. Howley (Ed.): Fields Virology . 4th edition, Philadelphia 2001, ISBN 0-7817-6060-7 .

[2] Y. Hu, X. Liu, A. Zhang, H. Zhou, Z. Liu, H. Chen, M. Jin: CHD3 facilitates vRNP nuclear export by interacting with NES1 of influenza A virus NS2. In: Cellular and molecular life sciences: CMLS. [Electronic publication before printing] September 2014, ISSN 1420-9071 , doi : 10.1007 / s00018-014-1726-9 , PMID 25213355 .

[3] K. Watanabe, T. Shimizu, S. Noda, F. Tsukahara, Y. Maru, N. Kobayashi: Nuclear export of the influenza virus ribonucleoprotein complex: Interaction of Hsc70 with viral proteins M1 and NS2. In: FEBS open bio. Volume 4, 2014, ISSN 2211-5463 , pp. 683-688, doi : 10.1016 / j.fob.2014.07.004 , PMID 25161876 , PMC 4141210 (free full text).

[4] D. Paterson, E. Fodor: Emerging roles for the influenza A virus nuclear export protein (NEP). In: PLoS pathogens. Volume 8, number 12, 2012, ISSN 1553-7374 , p. E1003019, doi : 10.1371 / journal.ppat.1003019 , PMID 23236273 , PMC 3516560 (free full text).