Matrix protein 1 (influenza virus A)

Matrix protein 1
	according to PDB 1EA3
Mass / length primary structure	252 amino acids , 28 kDa
Secondary to quaternary structure	multimer
Identifier
External IDs	UniProt : P03485 ;

The matrix protein 1 (M1) is a protein which in the virions of influenza viruses occurs and also determined its structure.

properties

The matrix protein 1 connects the virus envelope with the ribonucleoprotein in virions by binding to the nucleoprotein and through protein-lipid interactions with the virus envelope or with the cell membrane when new virions are formed . The binding to the lipids of the membrane triggers the multimerization of the M1 proteins. The newly formed virion assembles through the binding of the ribonucleoproteins.

During the infection process, influenza viruses are invaded into an endosome after binding to the cell by endocytosis . After acidification of the endosome and the M2 -mediated acidification of the interior of the virion, the fusion domain of the hemagglutinin penetrates the endosome membrane and releases the ribonucleoprotein into the cytosol . Due to the acidification of the virion, the matrix protein 1 separates from the ribonucleoprotein. Matrix protein 1 and NS2 are also involved in the export of the newly formed viral RNA from the cell nucleus .

The matrix protein 1 determines with the nucleoprotein which of the two forms of influenza virus the virion has, rod-shaped or egg-shaped. The shapes result from the length of the respective ribonucleoprotein.

Individual evidence

↑ M. Hilsch, B. Goldenbogen, C. Sieben, CT Höfer, JP Rabe, E. Klipp, A. Herrmann, S. Chiantia: Influenza A matrix protein M1 multimerizes upon binding to lipid membranes. In: Biophysical Journal. Volume 107, number 4, August 2014, ISSN 1542-0086 , pp. 912-923, doi : 10.1016 / j.bpj.2014.06.042 , PMID 25140426 , PMC 4142230 (free full text).
↑ EC Hutchinson, E. Fodor: Transport of the influenza virus genome from nucleus to nucleus. In: Viruses. Volume 5, number 10, October 2013, ISSN 1999-4915 , pp. 2424-2446, doi : 10.3390 / v5102424 , PMID 24104053 , PMC 3814596 (free full text).
↑ K. Watanabe, T. Shimizu, S. Noda, F. Tsukahara, Y. Maru, N. Kobayashi: Nuclear export of the influenza virus ribonucleoprotein complex: Interaction of Hsc70 with viral proteins M1 and NS2. In: FEBS open bio. Volume 4, 2014, ISSN 2211-5463 , pp. 683-688, doi : 10.1016 / j.fob.2014.07.004 , PMID 25161876 , PMC 4141210 (free full text).
↑ X. Huang, T. Liu, J. Muller, RA Levandowski, Z. Ye: Effect of influenza virus matrix protein and viral RNA on ribonucleoprotein formation and nuclear export. In: Virology. Volume 287, Number 2, September 2001, ISSN 0042-6822 , pp. 405-416, doi : 10.1006 / viro.2001.1067 , PMID 11531417 .

[1] M. Hilsch, B. Goldenbogen, C. Sieben, CT Höfer, JP Rabe, E. Klipp, A. Herrmann, S. Chiantia: Influenza A matrix protein M1 multimerizes upon binding to lipid membranes. In: Biophysical Journal. Volume 107, number 4, August 2014, ISSN 1542-0086 , pp. 912-923, doi : 10.1016 / j.bpj.2014.06.042 , PMID 25140426 , PMC 4142230 (free full text).

[2] EC Hutchinson, E. Fodor: Transport of the influenza virus genome from nucleus to nucleus. In: Viruses. Volume 5, number 10, October 2013, ISSN 1999-4915 , pp. 2424-2446, doi : 10.3390 / v5102424 , PMID 24104053 , PMC 3814596 (free full text).

[3] K. Watanabe, T. Shimizu, S. Noda, F. Tsukahara, Y. Maru, N. Kobayashi: Nuclear export of the influenza virus ribonucleoprotein complex: Interaction of Hsc70 with viral proteins M1 and NS2. In: FEBS open bio. Volume 4, 2014, ISSN 2211-5463 , pp. 683-688, doi : 10.1016 / j.fob.2014.07.004 , PMID 25161876 , PMC 4141210 (free full text).

[4] X. Huang, T. Liu, J. Muller, RA Levandowski, Z. Ye: Effect of influenza virus matrix protein and viral RNA on ribonucleoprotein formation and nuclear export. In: Virology. Volume 287, Number 2, September 2001, ISSN 0042-6822 , pp. 405-416, doi : 10.1006 / viro.2001.1067 , PMID 11531417 .