Nucleoside antibiotics
The nucleoside antibiotics are a group of antibiotics which are derived from nucleosides . They are not used in human medicine.
The nucleoside antibiotics have a similar structure, but differ in their mechanisms of action. The antibacterial nucleoside antibiotics inhibit the biosynthesis of the cell wall by inhibiting the bacterial translocase I (MraY). The fungicidal nucleoside antibiotics also act on the cell wall, but they inhibit chitin synthase . The antiviral nucleoside antibiotics block peptidyl transferase .
Classification
- Antibacterial ( uridine ) antibiotics
- Uridyl peptide antibiotics
- Uridyl lipopeptide antibiotics
- Uridyl lipodisaccharide antibiotics
- Uridyl glycosyl peptide antibiotics
- Fungicidal nucleoside antibiotics
- Antiviral nucleoside antibiotics
- Puromycin (derived from adenosine)
literature
- Michael Winn, Rebecca JM Goss, Ken-ichi Kimura, Timothy DH Bugg: Antimicrobial nucleoside antibiotics targeting cell wall assembly: Recent advances in structure – function studies and nucleoside biosynthesis . In: Natural Product Reports . tape 27 , no. 2 , 2010, p. 279 , doi : 10.1039 / b816215h .
- Guoqing Niu, Huarong Tan: Nucleoside antibiotics: biosynthesis, regulation, and biotechnology . In: Trends in Microbiology . 2014, doi : 10.1016 / j.tim.2014.10.007 .