Oligoadenylate synthetase 1

2'-5'-oligoadenylate synthase 1
other names	E18 / E16, p46 / p42 OAS, IFI-4, OIAS, OIASI
	Existing structure data : PDB 4IG8
Properties of human protein
Mass / length primary structure	400 amino acids , 46,029 Da
Identifier
External IDs	GeneCards : OAS1 ; OMIM : 164350 ; UniProt : P00973 ;
Enzyme classification
EC, category	2.7.7.84

The oligoadenylate synthetase 1 (synonymous 2'-5'-oligoadenylate synthetase 1 , OAS1) is an adenylyl synthetase and a resistance factor against viruses .

properties

The gene expression of OAS1 by interferons initiated. After binding dsRNA from adenosine triphosphate, OAS1 generates 2'-5'-oligoadenylate. The 2'-5'-oligoadenylate activates RNase L, which causes the breakdown of RNA in a cell . This temporarily reduces gene expression in the cell.

If an infection with West Nile virus OAS1 is by a stem-loop - secondary structure at the 5'-end of the viral RNA activated. Certain mutations in the OAS1 gene lead to an increased susceptibility to infections with West Nile viruses. Some mutations are prognostic markers for the course of multiple sclerosis .

Individual evidence

↑ VK Vachon, BM Calderon, GL Conn: A novel RNA molecular signature for activation of 2'-5 'oligoadenylate synthetase-1. In: Nucleic acids research. Volume 43, number 1, January 2015, pp. 544-552, doi : 10.1093 / nar / gku1289 , PMID 25477390 , PMC 4288181 (free full text).
↑ A. Mozzi, C. Pontremoli, D. Forni, M. Clerici, U. Pozzoli, N. Bresolin, R. Cagliani, M. Sironi: OasEs and Sting adaptive evolution in concert. In: Genome biology and evolution. [Electronic publication before printing] March 2015, doi : 10.1093 / gbe / evv046 , PMID 25752600 .
^ S. Deo, TR Patel, E. Dzananovic, EP Booy, K. Zeid, K. McEleney, SE Harding, SA McKenna: Activation of 2 '5'-oligoadenylate synthetase by stem loops at the 5'-end of the West Nile virus genome. In: PloS one. Volume 9, number 3, 2014, p. E92545, doi : 10.1371 / journal.pone.0092545 , PMID 24651762 , PMC 3961380 (free full text).
↑ JK Lim, A. Lisco, DH McDermott, L. Huynh, JM Ward, B. Johnson, H. Johnson, J. Pape, GA Foster, D. Krysztof, D. Follmann, SL Stramer, LB Margolis, PM Murphy: Genetic variation in OAS1 is a risk factor for initial infection with West Nile virus in man. In: PLoS pathogens. Volume 5, number 2, February 2009, p. E1000321, doi : 10.1371 / journal.ppat.1000321 , PMID 19247438 , PMC 2642680 (free full text).
↑ M. O'Brien, R. Lonergan, L. Costelloe, K. O'Rourke, JM Fletcher, K. Kinsella, C. Sweeney, G. Antonelli, KH Mills, C. O'Farrelly, M. Hutchinson, N Tubridy: OAS1: a multiple sclerosis susceptibility gene that influences disease severity. In: Neurology. Volume 75, Number 5, August 2010, pp. 411-418, doi : 10.1212 / WNL.0b013e3181ebdd2b , PMID 20679634 .

[1] VK Vachon, BM Calderon, GL Conn: A novel RNA molecular signature for activation of 2'-5 'oligoadenylate synthetase-1. In: Nucleic acids research. Volume 43, number 1, January 2015, pp. 544-552, doi : 10.1093 / nar / gku1289 , PMID 25477390 , PMC 4288181 (free full text).

[2] A. Mozzi, C. Pontremoli, D. Forni, M. Clerici, U. Pozzoli, N. Bresolin, R. Cagliani, M. Sironi: OasEs and Sting adaptive evolution in concert. In: Genome biology and evolution. [Electronic publication before printing] March 2015, doi : 10.1093 / gbe / evv046 , PMID 25752600 .

[3] S. Deo, TR Patel, E. Dzananovic, EP Booy, K. Zeid, K. McEleney, SE Harding, SA McKenna: Activation of 2 '5'-oligoadenylate synthetase by stem loops at the 5'-end of the West Nile virus genome. In: PloS one. Volume 9, number 3, 2014, p. E92545, doi : 10.1371 / journal.pone.0092545 , PMID 24651762 , PMC 3961380 (free full text).

[4] JK Lim, A. Lisco, DH McDermott, L. Huynh, JM Ward, B. Johnson, H. Johnson, J. Pape, GA Foster, D. Krysztof, D. Follmann, SL Stramer, LB Margolis, PM Murphy: Genetic variation in OAS1 is a risk factor for initial infection with West Nile virus in man. In: PLoS pathogens. Volume 5, number 2, February 2009, p. E1000321, doi : 10.1371 / journal.ppat.1000321 , PMID 19247438 , PMC 2642680 (free full text).

[5] M. O'Brien, R. Lonergan, L. Costelloe, K. O'Rourke, JM Fletcher, K. Kinsella, C. Sweeney, G. Antonelli, KH Mills, C. O'Farrelly, M. Hutchinson, N Tubridy: OAS1: a multiple sclerosis susceptibility gene that influences disease severity. In: Neurology. Volume 75, Number 5, August 2010, pp. 411-418, doi : 10.1212 / WNL.0b013e3181ebdd2b , PMID 20679634 .