Oxamniquin

Structural formula
Structural formula without stereochemistry
General
Surname	Oxamniquin
Molecular formula	C 14 H 21 N 3 O 3
Brief description	orange crystals
External identifiers / databases
CAS number 21738-42-1 EC number 244-556-4 ECHA InfoCard 100.040.491 PubChem 4612 DrugBank DB01096 Wikidata Q682497
Drug information
ATC code	P02 BA02 Q P52AA02
Drug class	Anthelmintic
properties
Molar mass	279.3 g · mol -1
Melting point	147-149 ° C 146–148 ° C ( polymorph I) 117–118 ° C (Polymorph II)
safety instructions
Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed GHS hazard labeling no classification available
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Oxamniquin is an anthelmintic with schistosomicidal activity against Schistosoma mansoni , but not against other Schistosoma spp. It is a potent single-dose drug used to treat infections in humans. It causes the worms to migrate from the mesenteric veins to the liver, where the male worms remain. The female worms return to the mesentery but are no longer able to lay eggs.

Stereochemistry

Oxamniquine contains a stereocenter and consists of two enantiomers. This is a racemate , i.e. a 1: 1 mixture of ( R ) - and ( S ) -form:

Enantiomers of Oxamniquine
( R ) shape	( S ) shape

Individual evidence

1. ↑ ^{a b c} Kuhnert-Brandstätter, M .; Völlenklee, R .: Contribution to the polymorphism of medicinal substances, Part 4: Oxamniquin, Resorantel, Spiperon, Suloctidil, Ticlopidinhydrochlorid, Parsol 1789 and Testosteroncyptonat in Sci. Pharm. 55 (1987) 27-39.
2. ^ The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals , 14th Edition (Merck & Co., Inc.), Whitehouse Station, NJ, USA, 2006; Pp. 1192-1193, ISBN 978-0-911910-00-1 .
3. ↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
4. ↑ Martidale: The Extra Pharmacopoeia , 31st edition, p 121st

This article is about a health issue. It is not used for self-diagnosis and does not replace a diagnosis by a doctor. Please note the information on health issues !