PAK3

from Wikipedia, the free encyclopedia
Serine / threonine protein kinase PAK 3
Serine / threonine protein kinase PAK 3
other names
  • Beta-PAH
  • Oligophrenine-3
  • p21 activated kinase 3

Existing structural data : 1e0a , 1ees , 1f3m , 1yhv , 1yhw , 2hy8

Properties of human protein
Identifier
Gene names PAK3 MRX30; MRX47; OPHN3
External IDs
Enzyme classification
EC, category 2.7.11.1
Orthologue
human House mouse
Entrez 5063 18481
Ensemble ENSG00000077264 ENSMUSG00000031284
UniProt O75914 Q61036
Refseq (mRNA) NM_001128166 NM_001195046
Refseq (protein) NP_001121638 NP_001181975
Gene locus Chr X: 110.94 - 111.23 Mb Chr X: 143.52 - 143.8 Mb
PubMed search 5063 18481

PAK 3 is an enzyme that is encoded by the PAK3 gene and belongs to the serine / threonine protein kinases . It plays an important role in various signal transduction processes in the cell, including cell migration , regulation of the cytoskeleton and the cell cycle .

family

The p21-activated kinase 3 belongs to the family of p21-activated kinases , which can be divided into two subfamilies: The first group consists of the enzymes PAK1 , PAK2 and PAK3, all of which are characterized by the fact that they bind to activated CDC42 and RAC1 are activated, while the second group around PAK4 , PAK6 and PAK5 is independent of CDC42 and RAC1.

Animal model

If PAK1 or PAK3 is inactivated, this has only moderate consequences in mice. Only the simultaneous inhibition of PAK1 and PAK3 leads to healthy born mice, but to severe defects in further brain development, which is due to reduced neuronal cell volume, a reduced number of axons and dendrites and a reduced synapse density. The mice then showed their behavior to be hyperactive and anxious and showed learning deficits; the electrophysiological activity in the hippocampus was abnormal and the activity of cofilin at the synapses was increased.

Individual evidence

  1. ↑ UniProt O75914
  2. ↑ PAK3.  In: Online Mendelian Inheritance in Man . (English)
  3. ↑ J. Eswaran, M. Soundararajan, R. Kumar, S. Knapp: UnPAKing the class differences among p21-activated kinases . In: Trends in Biochemical Sciences . tape 33 , no. 8 , August 2008, p. 394-403 , doi : 10.1016 / j.tibs.2008.06.002 , PMC 18639460 (free full text).
  4. ^ S. Asrar, Y. Meng, Z. Zhou, Z. Todorovski, WW Huang, Z. Jia: Regulation of hippocampal long-term potentiation by p21-activated protein kinase 1 (PAK1). In: Neuropharmacology. Volume 56, number 1, January 2009, pp. 73-80, doi: 10.1016 / j.neuropharm.2008.06.055 . PMID 18644395 .
  5. Jump up ↑ J. Meng, Y. Meng, A. Hanna, C. Janus, Z. Jia: Abnormal long-lasting synaptic plasticity and cognition in mice lacking the mental retardation gene Pak3. In: The Journal of neuroscience: the official journal of the Society for Neuroscience. Volume 25, number 28, July 2005, pp. 6641-6650, doi: 10.1523 / JNEUROSCI.0028-05.2005 . PMID 16014725 .
  6. ↑ W. Huang, Z. Zhou, S. Asrar, M. Henkelman, W. Xie Z. Jia: p21-Activated kinases 1 and 3 control brain size through coordinating neuronal complexity and synaptic properties . In: Molecular and cellular biology . tape 31 , no. 3 , February 2012, p. 388-403 , doi : 10.1128 / MCB.00969-10 , PMID 21115725 , PMC 3028630 (free full text).