PAK2
| Serine / threonine protein kinase PAK2 | ||
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| Properties of human protein | ||
| Identifier | ||
| Gene name | PAK2 | |
| External IDs | ||
| Enzyme classification | ||
| EC, category | 2.7.11.1 | |
| Orthologue | ||
| human | House mouse | |
| Entrez | 5062 | 224105 |
| Ensemble | ENSG00000180370 | ENSMUSG00000022781 |
| UniProt | Q13177 | Q8CIN4 |
| Refseq (mRNA) | NM_002577 | NM_177326 |
| Refseq (protein) | NP_002568 | NP_796300 |
| Gene locus | Chr 3: 196.74 - 196.83 Mb | Chr 16: 32.02 - 32.08 Mb |
| PubMed search | 5062 |
224105
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PAK 2 is an enzyme that is encoded by the PAK2 gene and belongs to the serine / threonine protein kinases . It plays an important role in various signal transduction pathways , including regulation of the cytoskeleton , cell motility , control of the cell cycle , apoptosis and cell proliferation . The enzyme is activated by the binding of active CDC42 and RAC1 , resulting in a change in the conformation of the protein and subsequent auto- phosphorylation of serine and / or threonine - amino acids has the protein result.
The p21-activated kinase 2 belongs to the family of p21-activated kinases , which can be divided into two subfamilies: The first group consists of the enzymes PAK1 , PAK2 and PAK3 , all of which are characterized by the fact that they bind to activated CDC42 and RAC1 are activated, while the second group around PAK4 , PAK6 and PAK5 is independent of CDC42 and RAC1.
Individual evidence
- ↑ UniProt Q13177
- ↑ PAK2. In: Online Mendelian Inheritance in Man . (English)
- ↑ J. Eswaran, M. Soundararajan, R. Kumar and S. Knapp: UnPAKing the class differences among p21-activated kinases . In: Trends in Biochemical Sciences . 33, No. 8, August 2008, pp. 394-403. doi : 10.1016 / j.tibs.2008.06.002 . PMC 18639460 (free full text).