PAK6
| Serine / threonine protein kinase PAK 6 | ||
|---|---|---|
|
||
| other names |
p21 activated kinase 6 |
|
| Properties of human protein | ||
| Mass / length primary structure | 74,869 Daltons / 681 amino acids (Isoform1) or
|
|
| Isoforms | 2 | |
| Identifier | ||
| Gene names | PAK6 PAK5 | |
| External IDs | ||
| Enzyme classification | ||
| EC, category | 2.7.11.1 | |
| Orthologue | ||
| human | House mouse | |
| Entrez | 56924 | 214230 |
| Ensemble | ENSG00000137843 | ENSMUSG00000074923 |
| UniProt | Q9NQU5 | Q3ULB5 |
| Refseq (mRNA) | NM_001128628 | NM_001033254 |
| Refseq (protein) | NP_001122100 | NP_001028426 |
| Gene locus | Chr 15: 40.22 - 40.28 Mb | Chr 2: 118.66 - 118.7 Mb |
| PubMed search | 56924 |
214230
|
PAK6 , also known as PAK5 , is a gene that codes for the serine / threonine protein kinase PAK6. The enzyme plays a role in regulating gene transcription . It is activated by various effectors, including the androgen receptor (AR) or MAP2K6 / MAPKK6 . The kinase phosphorylates the DNA-binding domain of the androgen receptor and thus prevents AR-mediated transcription and also ESR1 -mediated transcription. It is also possible that PAK6 plays a role in regulating the cytoskeleton by interacting with IQGAP1 , and that it protects cells from apoptosis by phosphorylation of BAD .
family
The p21-activated kinase 6 belongs to the family of p21-activated kinases , which comprises two subfamilies: PAK1 , PAK2 and PAK3 are activated by binding to activated CDC42 and RAC1, while PAK4 and PAK-5 act independently thereof.
Individual evidence
- ↑ UniProt Q9NQU5
- ↑ PAK6. In: Online Mendelian Inheritance in Man . (English)
- ↑ J. Eswaran, M. Soundararajan, R. Kumar and S. Knapp: UnPAKing the class differences among p21-activated kinases . In: Trends in Biochemical Sciences . 33, No. 8, August 2008, pp. 394-403. doi : 10.1016 / j.tibs.2008.06.002 . PMC 18639460 (free full text).