Pathergy phenomenon

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A pathergy phenomenon (from patho -, a Latin word formation element for "disease", ancient Greek ἔργον érgon , German 'work, activity' and φαινόμενον phainómenon , German 'appearance' ) is understood to be the triggering of a disease-specific lesion through a non-specific stimulus , a characteristic, clinical findings also used for diagnostic purposes. It is the clinical manifestation of a lowered threshold for activation of neutrophils .

The term pathergy was coined by the German pathologist Robert Rössle as a term for all acquired, pathologically increased or decreased changes in reactivity. Subordinate to the generic term are the specific pathergy or allergy on the one hand and the non-specific pathergy (parallergy, allophlogisty, Sanarelli-Shwartzman reaction and the so-called physical allergy) on the other.

The pathergy phenomenon can be observed in Behçet's disease , among others . After injection of 0.5 ml of a 0.9 percent ( isotonic ) NaCl solution , pustules appear at the injection site after 48 hours . In Behçet's disease, this pathergy phenomenon is pathognomonic . In pyoderma gangrenosum , ulcerative dermatitis , it occurs after minimal trauma, for example after needle pricks as part of an intracutaneous test , after which the minimal trauma transforms into hemorrhagic , necrotizing pustules from which a new focus can arise. The pathergy phenomenon can also be observed in granulomatosis with polyangiitis (Wegener's granulomatosis) and leukocytoclastic vasculitis .

See also

Web links

Wiktionary: Pathergy phenomenon  - explanations of meanings, word origins , synonyms, translations

Individual evidence

  1. ↑ pathergy , The Great Fremdwörterbuch Academic. Retrieved November 12, 2017.
  2. ^ A b Peter Fritsch: Dermatology Venerology: Basics. Clinic. Atlas. . Springer-Verlag, December 18, 2013, ISBN 978-3-662-06555-6 , p. 390.
  3. ↑ Lothar Kerp: Allergy and allergic reactions. In: Ludwig Heilmeyer (ed.): Textbook of internal medicine. Springer-Verlag, Berlin / Göttingen / Heidelberg 1955; 2nd edition ibid. 1961, pp. 1130–1159, here: pp. 1136–1138 ( definitions of the allergy theory ).
  4. ^ Rudolf Ott, Wolfgang Krug, Hans-Peter Vollmer: Clinic and Practice Guide Dentistry . Georg Thieme Verlag, December 18, 2002, ISBN 978-3-13-158021-4 , p. 294.