Phospholamban

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Phospholamban
Phospholamban
Ribbon model of the pentamer according to PDB  1ZLL

Existing structural data : 1n7l , 1zll , 1fjk , 1fjp , 2hyn

Properties of human protein
Mass / length primary structure 52 amino acids
Secondary to quaternary structure Homopentamer
Identifier
Gene names PLN  ; PLB
External IDs
Transporter classification
TCDB 1.A.50.1.1
designation Phospholamban family

Phospholamban (PLB, PLN) is a protein in heart muscle cells that controls the uptake of Ca 2+ in the sarcoplasmic reticulum : In the dephosphorylated state, it inhibits SERCA (Sarcoplasmic / endoplasmic reticulum calcium ATPase), a Ca which is integrated into the membrane of the sarcoplasmic reticulum 2+ pump. After β-adrenergic stimulation of the myocardial cell, phospholamban is phosphorylated by protein kinase A , its inhibitory effect is canceled, so that more Ca 2+ is absorbed into the sarcoplasmic reticulum and the myocardial cell can relax more quickly. The protein therefore has a positive lusitropic effect in the phosphorylated state .

Mutations in the PLB gene can cause the rare type 1P dilated cardiomyopathy .

Individual evidence

  1. UniProt O14983
  2. UniProt entry