Phospholamban
| Phospholamban | ||
|---|---|---|
|
||
| Ribbon model of the pentamer according to PDB 1ZLL | ||
| Properties of human protein | ||
| Mass / length primary structure | 52 amino acids | |
| Secondary to quaternary structure | Homopentamer | |
| Identifier | ||
| Gene names | PLN ; PLB | |
| External IDs | ||
| Transporter classification | ||
| TCDB | 1.A.50.1.1 | |
| designation | Phospholamban family | |
Phospholamban (PLB, PLN) is a protein in heart muscle cells that controls the uptake of Ca 2+ in the sarcoplasmic reticulum : In the dephosphorylated state, it inhibits SERCA (Sarcoplasmic / endoplasmic reticulum calcium ATPase), a Ca which is integrated into the membrane of the sarcoplasmic reticulum 2+ pump. After β-adrenergic stimulation of the myocardial cell, phospholamban is phosphorylated by protein kinase A , its inhibitory effect is canceled, so that more Ca 2+ is absorbed into the sarcoplasmic reticulum and the myocardial cell can relax more quickly. The protein therefore has a positive lusitropic effect in the phosphorylated state .
Mutations in the PLB gene can cause the rare type 1P dilated cardiomyopathy .