Phosphomannomutase
| Phosphomannomutase | ||
|---|---|---|
| Identifier | ||
| Gene name (s) | PMM1 , PMM2 | |
| Enzyme classification | ||
| EC, category | 5.4.2.8 , isomerase | |
| Response type | Rearrangement | |
| Substrate | Mannose-1-phosphate | |
| Products | Mannose-6-phosphate | |
| Occurrence | ||
| Parent taxon | Eukaryotes , bacteria | |
Phosphomannomutases are enzymes in eukaryotes and bacteria that catalyze the rearrangement of mannose-1-phosphate to mannose-6-phosphate and vice versa . Eukaryotes require GDP-mannose for the glycosylation of proteins, bacteria use mannose as an energy supplier. Two paralogous isoforms of the enzyme are known in humans, designated PMM-1 and PMM-2. PMM-1 is particularly produced in the liver , heart , brain and pancreas . Mutations in the PMM2 gene can lead to a rare hereditary glycosylation defect type 1a (CDG-1a).
Catalyzed reaction
⇔ 
α- D- mannose-1-phosphate and β- D- mannose-6-phosphate merge.
Individual evidence
Web links
Wikibooks: Biochemistry and Pathobiochemistry: Fructose, Mannose and Fucose Metabolism - Learning and Teaching Materials
