GDP mannose
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| Surname | GDP mannose | ||||||||||||
| Molecular formula | C 16 H 25 N 5 O 16 P 2 | ||||||||||||
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| Molar mass | 605.34 g mol −1 | ||||||||||||
| Physical state |
firmly |
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| As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . | |||||||||||||
The GDP-mannose or guanosine diphosphate - mannose is a nucleoside diphosphate sugar in the cytosol formed and in the Golgi apparatus to the glycosylation needed is.
Manufacturing
GDP-mannose plays a role in the fucosylation of oligosaccharides . GDP-mannose releases its energy during glycan biosynthesis.
GDP-mannose is made by three different enzymes : phosphomannose isomerase isomerizes D - fructose-6-phosphate to D - mannose-6-phosphate , and phosphomannomutase further changes it to D - mannose-1-phosphate . The synthesis is completed by GDP-Man pyrophosphorylase .
GDP mannose transporter
GDP mannose transporters are essential for the transport between the cytoplasm and the Golgi apparatus . GDP-mannose itself is negatively charged and therefore cannot pass through the biomembrane by itself .
See also
Individual evidence
- ↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
- ↑ GDP-mannose. Spektrum Akademischer Verlag Heidelberg, 1999, accessed on February 28, 2018 .
- ↑ Masato Abe, Yoichi Noda, Hiroyuki Adachi, Koji Yoda: Localization of GDP-mannose transporter in the Golgi requires retrieval to the endoplasmic reticulum depending on its cytoplasmic tail and coatomer . In: Journal of Cell Science . tape 117 , Pt 23, November 1, 2004, p. 5687-5696 , doi : 10.1242 / jcs.01491 , PMID 15494368 .