Fructose-6-phosphate

Structural formula
	Open form (left) and ring representation (right) of D- fructose-6-phosphate under physiological conditions
General
Surname	D- fructose-6-phosphate
other names	[(2 R , 3 R , 4 S ) -3,4,5-trihydroxy-5- (hydroxymethyl) oxolan-2-yl] methoxyphosphonic acid; Neuberg -Ester;
Molecular formula	C 6 H 13 O 9 P; C 6 H 11 O 9 P 2− (under physiological conditions);
External identifiers / databases
EC number	211-395-6
ECHA InfoCard	100.010.360
PubChem	69507
DrugBank	DB04493
Wikidata	Q32039197
properties
Molar mass	262.15 g mol −1
safety instructions
GHS hazard labeling ; no classification available
GHS hazard labeling ; no classification available
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

D- fructose-6-phosphate , a phosphoric acid ester of fructose , is an important metabolite of many metabolic processes. Under physiological conditions at a pH of 7, the ester is present as an anion (see picture).

Most important is its occurrence in glycolysis and gluconeogenesis and thus also in alcoholic fermentation . It also plays a role in the photosynthesis of plants in the Calvin cycle . Finally, D- fructose-6-phosphate is required for the biosynthesis of sucrose in plants.

There are two important derivatives , an intermediate and a regulator of the glycolysis pathway:

Fructose-1,6-bisphosphate (Frc-1,6-BP), the product of phosphofructokinase 1 (PFK 1), at the same time substrate of aldolase ;
Fructose-2,6-bisphosphate (Frc-2,6-BP), the product of phosphofructokinase 2 (PFK 2), at the same time an important activator of PFK 1.

Individual evidence

↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
^ H. Robert Horton, Laurence A. Moran, K. Gray Scrimgeour, Marc D. Perry, J. David Rawn and Carsten Biele (translators): Biochemie . Pearson Studies; 4th updated edition 2008; ISBN 978-3-8273-7312-0 ; P. 634.