Metabolites are the products of enzyme-catalyzed reactions that occur naturally in cells . To be classified as a metabolite, a compound must meet the following criteria:
- The metabolites are chemical compounds that are found within cells.
- Metabolites arise through the influence of enzymes .
- Metabolites must be able to enter into subsequent reactions
- The metabolites have a finite half-life ; they do not accumulate in cells.
- Many metabolites are regulators that control the individual steps of the metabolism.
- Metabolites must perform useful biological functions in the cell.
The metabolism (also metabolism ) consists of many individual series of enzymatic conversions that deliver specific products. These intermediate products (each reaction step has at least one substrate and at least one product ) are known as metabolites . The totality of the metabolites of a cell at a defined point in time is called the metabolome . Various side reactions can cause metabolite damage.
Secondary metabolites are chemical compounds that are synthesized by certain living things ( bacteria , fungi , plants ). In contrast to primary metabolites such as sugar or amino acids , these substances are not essential for the producing organism.
- Phenacetin is converted to the metabolite paracetamol .
- Heroin is converted to the metabolite morphine .
- Jeremy M. Berg, John L. Tymoczko, Lubert Stryer : Biochemistry. 6th edition, Spektrum Akademischer Verlag, Heidelberg 2007, ISBN 978-3-8274-1800-5 .
- Donald Voet, Judith G. Voet: Biochemistry. 4th edition. John Wiley & Sons, New York 2011, ISBN 978-1-118-13992-9 .
- Bruce Alberts , Alexander Johnson, Peter Walter, Julian Lewis, Martin Raff, Keith Roberts: Molecular Biology of the Cell. 4th edition. Taylor & Francis, 2002, ISBN 978-0-8153-3218-3 .
- Edward D. Harris, Biochemical Facts behind the Definition and Properties of Metabolites . US Food and Drug Administration (FDA). Retrieved May 2, 2016.