Phosphopantothenoylcysteine decarboxylase
| Phosphopantothenoylcysteine decarboxylase | ||
|---|---|---|
| Properties of human protein | ||
| Mass / length primary structure | 204 amino acids | |
| Secondary to quaternary structure | Homotrimer | |
| Cofactor | FMN | |
| Isoforms | 2 | |
| Identifier | ||
| Gene name | PPCDC | |
| External IDs | ||
| Enzyme classification | ||
| EC, category | 4.1.1.36 , lyase | |
| Response type | Decarboxylation | |
| Substrate | Phosphopantothenoyl-L-cysteine | |
| Products | 4'-pantethine phosphate + CO 2 | |
| Occurrence | ||
| Homology family | PPC-DC | |
| Parent taxon | Creature | |
| Orthologue | ||
| human | House mouse | |
| Entrez | 60490 | 66812 |
| Ensemble | ENSG00000138621 | ENSMUSG00000063849 |
| UniProt | Q96CD2 | Q8BZB2 |
| Refseq (mRNA) | NM_021823 | XM_006511361 |
| Refseq (protein) | NP_068595 | XP_006511424 |
| Gene locus | Chr 15: 75.02 - 75.05 Mb | Chr 9: 57.39 - 57.44 Mb |
| PubMed search | 60490 |
66812
|
Phosphopantothenoylcysteine decarboxylase (PPC-DC) is the enzyme that the elimination of carbon dioxide from Phosphopantothenoyl-cysteine catalysed . This is the third reaction step in the biosynthesis of coenzyme A , which takes place in most living things.
Catalyzed reaction
-4%27-Phosphopantothenoyl-L-cystein.svg)
+ CO 2
(R) -4'-phosphopantothenoyl-L-cysteine is decarboxylated to form 4'-phosphopantethenine . The enzyme binds one molecule of FMN per subunit as a cofactor . So it is a flavoprotein .
Individual evidence
Web links
Wikibooks: Biochemistry and Pathobiochemistry: Pantothenate Metabolism - Learning and Teaching Materials
