Propanoyl-CoA acyltransferase
| Propanoyl-CoA acyltransferase | ||
|---|---|---|
| Properties of human protein | ||
| Mass / length primary structure | 547 amino acids | |
| Isoforms | SCPx, SCP2 | |
| Identifier | ||
| Gene name | SCP2 | |
| External IDs | ||
| Enzyme classification | ||
| EC, category | 2.3.1.176 , transferase | |
| Response type | Transfer of a propanoic acid residue | |
| Substrate | 3α, 7α, 12α-trihydroxy-5β-24-oxo-cholestanoyl-CoA + CoA-SH | |
| Products | Choloyl-CoA + propanoyl-CoA | |
| Occurrence | ||
| Parent taxon | Animals, mushrooms | |
Propanoyl-CoA acyltransferase (also: sterol carrier protein (SCP) , non-specific lipid-transfer protein ) is the enzyme in animals and fungi, that the biosynthesis of choloyl-CoA, a precursor of the cholic acid (a bile acid ) catalyzed . It is localized in the cytosol and mitochondria of the peroxisomes . It binds to PEX5 for peroxisome import . In humans, SCP is mainly produced in the liver , fibroblasts and placenta . In Zellweger's syndrome , the SCP activity is reduced due to the lack of peroxisomes.
Catalyzed reaction
+ CoA -SH ⇒
⇒ 
+
Propanoic acid is transferred from 3α, 7α, 12α-trihydroxy-5β-24-oxo-cholestanoyl-CoA to CoA-SH, choloyl-CoA and propanoyl-CoA are formed.
Individual evidence
Web links
Wikibooks: Biochemistry and Pathobiochemistry: Bile Acid Metabolism - Learning and Teaching Materials
