Prostaglandin H 2
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| Surname | Prostaglandin H2 | |||||||||
| Molecular formula | C 20 H 32 O 5 | |||||||||
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| Molar mass | 352.46 g · mol -1 | |||||||||
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| As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . | ||||||||||
Prostaglandin H 2 (PGH 2 ) is an intermediate product of prostaglandin synthesis in vertebrates . It is formed biosynthetically in two steps from arachidonic acid by the cyclooxygenases . PGH 2 stimulates inflammatory reactions and regulates the secretion of gastric juice . The aspirin achieves its effect by inhibiting the cyclooxygenase. Acetylsalicylic acid acetylates the Ser530 of the prostaglandin H synthase and thus blocks the channel so that the arachidonic acid can no longer get from the membrane into the active center of the enzyme.
Prostaglandin H 2 is the starting substance for other hormones: prostaglandin I 2 , prostaglandin E 2 , prostaglandin D 2 and prostaglandin F 2 as well as thromboxane A 2 .
Individual evidence
- ↑ a b Data sheet Prostaglandin H 2 , ≥95% (HPLC), acetonitrile solution from Sigma-Aldrich , accessed on October 31, 2016 ( PDF ).