Protein M

from Wikipedia, the free encyclopedia

The M protein is a protein of Mycoplasma genitalium , the antibody binds.

properties

Protein M is used for immune evasion and is a virulence factor . The binding of antibodies reduces an antigen-antibody reaction . M protein has 556 amino acids and has low homology to other bacterial antibody-binding proteins such as Protein A , Protein G , Protein A / G or protein L . The N -terminal protein domain of protein M binds to the variable regions of the light chains of human immunoglobulins of all types, while the C -terminal protein domain protrudes somewhat from the molecule and binds to κ or λ light chains of immunoglobulins.

Individual evidence

  1. Jump up ↑ RK Grover, X. Zhu, T. Nieusma, T. Jones, I. Boero, AS MacLeod, A. Mark, S. Niessen, HJ Kim, L. Kong, N. Assad-Garcia, K. Kwon, M. Chesi, VV Smider, DR Salomon, DF Jelinek, RA Kyle, RB Pyles, JI Glass, AB Ward, IA Wilson, RA Lerner: A structurally distinct human mycoplasma protein that generically blocks antigen-antibody union. In: Science. Volume 343, number 6171, February 2014, pp. 656-661, doi : 10.1126 / science.1246135 , PMID 24503852 , PMC 3987992 (free full text).