Psoriasin

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Psoriasin
Psoriasin
according to PDB  1PSR
other names
  • Protein S100A7
  • S100 calcium-binding protein A7

Existing structural data : 1PSR , 2WND , 3PSR , 1PSR

Properties of human protein
Mass / length primary structure 11.471 kDa / 101 AS
Identifier
Gene names S100A7 PSOR1 S100A7C
External IDs
Occurrence
Homology family HOG000154231

S100 calcium-binding protein A7 ( S100A7 ), also known as psoriasin , is a protein from the group of S-100 proteins that is encoded by the S100A7 gene in humans .

function

S100A7 is a member of the S100 protein family and contains two calcium-binding EF hand motifs. S100 proteins are located in the cytoplasm and / or nucleus of a wide range of cells and are involved in the regulation of a number of cellular processes, such as the progression of the cell cycle and cell differentiation . The group of S100 genes contains at least 13 members that are located in a cluster on chromosome 1q21. S100A7 differs from the other S100 proteins with a known structure in that it lacks the possibility of calcium binding in an EF hand at the N terminus .

The protein also functions as a prominent antimicrobial peptide , mainly against Escherichia coli . It is secreted by epithelial cells of the skin and acts as a key protein against E. coli by disrupting the structure of its cell membranes. This is one reason why, in countries with poor hygienic conditions , infections normally do not occur from faeces despite frequent skin contact with E. coli strains.

S100A7 is highly homologous to S100A15 ( Koebnerisin ), but differs in gene expression , in tissue occurrence and in function.

Clinical significance

This protein is clearly overexpressed in psoriasis skin lesions , but is excluded as a candidate for familial accumulation of this disease. The serum concentration of psoriasin is also increased in psoriasis patients and patients with other inflammatory dermatoses. The expression of psoriasin is induced in skin injuries by activating the EGF receptor .

Interactions

It could be shown that S100A7 interacts with COPS5 , FABP5 and RANBP9 .

It also shows interaction with RAGE ( receptor of advanced glycated end products ).

Individual evidence

  1. ↑ a b UniProt P31151
  2. ↑ a b Entry on S100A7 in the gene database of the National Center for Biotechnology Information (NCBI).
  3. ↑ Philippe Bulet, Reto Stöcklin, Laure Menin: Anti-microbial peptides: from invertebrates to vertebrates . In: Immunological Reviews . tape 198 , no. 1 , April 2004, p. 169-184 , doi : 10.1111 / j.0105-2896.2004.0124.x .
  4. ↑ Ronald Wolf, OM Zack Howard, Hui-Fang Dong, Christopher Voscopoulos, Karen Boeshans, Jason Winston, Rao Divi, Michele Gunsior, Paul Goldsmith, Bijan Ahvazi, Triantafyllos Chavakis, Joost J. Oppenheim, Stuart H. Yuspa: Chemotactic activity of S100A7 (psoriasin) is mediated by the receptor for advanced glycation end products and potentiates inflammation with highly homologous but functionally distinct S100A15 . In: Journal of Immunology . tape 181 , no. 2 , July 2008, p. 1499-1506 , PMID 18606705 , PMC 2435511 (free full text).
  5. ↑ Ronald Wolf, Christopher Voscopoulos, Jason Winston, Alif Dharamsi, Paul Goldsmith, Michele Gunsior, Barbara K. Vonderhaar, Melanie Olson, Peter H. Watson, Stuart H. Yuspa: Highly homologous hS100A15 and hS100A7 proteins are distinctly expressed in normal breast tissue and breast cancer . In: Cancer letters . tape 277 , no. 1 , May 2009, p. 101-107 , doi : 10.1016 / j.canlet.2008.11.032 , PMC 2680177 (free full text).
  6. ↑ S. Zwicker, D. Bureik, T. Ruzicka, R. Wolf: [Friend or Foe? Psoriasin and Koebnerisin: multifunctional defense molecules in skin differentiation, tumorigenesis and inflammation] . In: German Medical Weekly . tape 137 , no. 10 , March 2012, p. 491-494 , doi : 10.1055 / s-0031-1299015 , PMID 22374659 .
  7. ↑ Zuzana Hegyi, Stephanie Zwicker, Daniela Bureik, Mark Peric, Sarah Koglin, Aleksandra Batycka-Baran, Jörg C. Prinz, Thomas Ruzicka, Jürgen Schauber, Ronald Wolf: Vitamin D analog calcipotriol suppresses the Th17 cytokine-induced proinflammatory S100 “alarmins” psoriasin (S100A7) and koebnerisin (S100A15) in psoriasis . In: The Journal of Investigative Dermatology . tape 132 , no. 5 , May 2012, p. 1416-1424 , doi : 10.1038 / jid.2011.486 , PMID 22402441 .
  8. ↑ Dorothea Elisabeth Eisenbeiß: Investigations on the importance of the antimicrobial peptide "psoriasin" in the serum of psoriasis patients . Kiel 2010, DNB  1011244365 (dissertation).
  9. ↑ Kathleen C. Lee, Richard L. Eckert: S100A7 (Psoriasin) - mechanism of antibacterial action in wounds . In: The Journal of Investigative Dermatology . tape 127 , no. 4 , April 2007, pp. 945-957 , doi : 10.1038 / sj.jid.5700663 , PMID 17159909 .
  10. ↑ Ethan D. Emberley, Yulian Niu, Etienne Leygue, Ladislav Tomes, R. Daniel Gietz, Leigh C. Murphy, Peter H. Watson: Psoriasin interacts with Jab1 and influences breast cancer progression . In: Cancer Research . tape 63 , no. 8 , April 2003, p. 1954-1961 , PMID 12702588 .
  11. ↑ Monica Ruse, Ann-Marie Broome, Richard L. Eckert: S100A7 (psoriasin) interacts with epidermal fatty acid binding protein and localizes in focal adhesion-like structures in cultured keratinocytes . In: The Journal of Investigative Dermatology . tape 121 , no. 1 , July 2003, p. 132-141 , doi : 10.1046 / j.1523-1747.2003.12309.x , PMID 12839573 .
  12. ↑ G. Hagens, K. Roulin, R. Hotz, JH Saurat, U. Hellman, G. Siegenthaler: Probable interaction between S100A7 and E-FABP in the cytosol of human keratinocytes from psoriatic scales . In: Molecular and Cellular Biochemistry . tape 192 , no. 1-2 , February 1999, pp. 123-128 , doi : 10.1023 / A: 1006894909694 , PMID 10331666 .
  13. ↑ Ethan D. Emberley, R. Daniel Gietz, J. Darren Campbell, Kent T. HayGlass, Leigh C. Murphy, Peter H. Watson: RanBPM interacts with psoriasin in vitro and their expression correlates with specific clinical features in vivo in breast cancer . In: BMC cancer . tape 2 , November 2002, p. 28 , doi : 10.1186 / 1471-2407-2-28 , PMID 12421467 , PMC 137593 (free full text).
  14. ↑ Ronald Wolf, OM Zack Howard, Hui-Fang Dong, Christopher Voscopoulos, Karen Boeshans, Jason Winston, Rao Divi, Michele Gunsior, Paul Goldsmith, Bijan Ahvazi, Triantafyllos Chavakis, Joost J. Oppenheim, Stuart H. Yuspa: Chemotactic activity of S100A7 (psoriasin) is mediated by the receptor for advanced glycation end products and potentiates inflammation with highly homologous but functionally distinct S100A15 . In: Journal of Immunology . tape 181 , no. 2 , July 2008, p. 1499-1506 , PMID 18606705 , PMC 2435511 (free full text).
  15. ↑ Jason Winston, Ronald Wolf: Psoriasin (S100A7) promotes migration of a squamous carcinoma cell line . In: Journal of Dermatological Science . tape 67 , no. 3 , September 2012, p. 205-207 , doi : 10.1016 / j.jdermsci.2012.06.009 , PMID 22795619 .