Powder injection
The powder injection is under development seeding method without cannula , which is a form of administration for drugs . The drug is administered in dried or lyophilized form. Powder injection is a variant of needle-free injection . As a needle-free form of application, powder injection, like jet injection , is minimally invasive .
In powder injection, the powdered vaccine is brought to high speed with the help of a compressed gas and penetrates the skin due to its mass and acceleration . The powdery particles have a diameter between 20 and 100 micrometers . The injection is almost painless. The vaccine penetrates to the epidermis and, in the case of vaccines, triggers the immune reaction there.
The gene gun is a method of powder injection of DNA .
Individual evidence
- ^ NT Weissmueller, L. Marsay, HA Schiffter, RC Carlisle, CS Rollier, RK Prud'homme, AJ Pollard: Alternative vaccine administration by powder injection: Needle-free dermal delivery of the glycoconjugate meningococcal group Y vaccine. In: PLOS ONE . Volume 12, number 8, 2017, p. E0183427, doi : 10.1371 / journal.pone.0183427 , PMID 28837693 , PMC 5570268 (free full text).
- ↑ L. Engelke, G. Winter, S. Hook, J. Engert: Recent insights into cutaneous immunization: How to vaccinate via the skin. In: Vaccine . Volume 33, number 37, September 2015, pp. 4663-4674, doi : 10.1016 / j.vaccine.2015.05.012 , PMID 26006087 .
- ↑ a b T. L. Burkoth, BJ Bellhouse, G. Hewson, DJ Longridge, AG Muddle, DF Sarphie: Transdermal and transmucosal powdered drug delivery. In: Critical reviews in therapeutic drug carrier systems. Volume 16, Number 4, 1999, pp. 331-384, PMID 10532199 .