Needle-free injection

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intradermal injection
functionality

In a needle-free injection ( "needleless syringe," eng. Jet injection ) is a drug or a substance by means of a vaccination gun by high pressure directly without the use of a cannula into the body of humans or animals injected .

The systems are not designed for the collection of liquids, e.g. B. blood, suitable. It is used subcutaneously and intradermally , but not deep in the tissue and not intravenously .

application areas

It is possible to administer both liquid and powdery substances that are applied by means of a spring or gas. In addition to various possible applications ( diabetics , local anesthesia , thrombosis prophylaxis ), there is above all potential for mass vaccinations, for example in the context of a pandemic. The gene cannon is a device for needle-free injection.

In the swine vaccination sector, needleless vaccination systems have been on the market since 2016. The injection volumes of approx. 0.2 ml are applied intradermally at high pressure. It is vaccinated against, for example, the porcine circovirus , suides herpesvirus 1 and Mycoplasma hyopneumoniae .

advantages

The manufacturers proclaim that they are largely free of pain and that the dosage is more precise. Needlestick injuries are generally excluded.

disadvantage

The devices are less suitable for larger amounts of substance above 0.5 ml. The technical complexity and the price of the systems are higher than for syringes with needles.

See also

Individual evidence

  1. ↑ J. Baxter, S. Mitragotri: Needle-free liquid jet injections: mechanisms and applications. In: Expert review of medical devices. Volume 3, Number 5, September 2006, ISSN  1743-4440 , pp. 565-574, doi : 10.1586 / 17434440.3.5.565 , PMID 17064242 (review).
  2. ^ G. Kersten, H. Hirschberg: Needle-free vaccine delivery. In: Expert opinion on drug delivery. Volume 4, Number 5, September 2007, ISSN  1742-5247 , pp. 459-474, doi : 10.1517 / 17425247.4.5.459 , PMID 17880271 (review).
  3. ^ New needle free vaccine for pig disease. May 13, 2016. Retrieved January 26, 2017 .
  4. ↑ M. Borggren, J. Nielsen u. a .: Vector optimization and needle-free intradermal application of a broadly protective polyvalent influenza A DNA vaccine for pigs and humans. In: Human vaccines & immunotherapeutics. Volume 11, number 8, 2015, pp. 1983–1990, doi : 10.1080 / 21645515.2015.1011987 , PMID 25746201 , PMC 4635702 (free full text).