PyOxime

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Structural formula
Structural formula of the title substance
General
Surname PyOxime
other names

[Ethyl cyano (hydroxyimino) acetato- O 2 ] tri-1-pyrrolidinylphosphonium hexafluorophosphate

Molecular formula C 17 H 29 F 6 N 5 O 3 P 2
External identifiers / databases
CAS number 153433-21-7
Wikidata Q27902940
properties
Molar mass 527.38 g mol −1
safety instructions
GHS labeling of hazardous substances
no GHS pictograms
H and P phrases H: no H-phrases
P: no P-phrases
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

PyOxim is a coupling reagent from the group of phosphonium salts. In solid phase peptide synthesis , it reacts faster than PyBOP , but more slowly than COMU , HCTU and HATU, among others . In contrast to HATU and HBTU , it does not lead to chain terminations and is therefore used for the synthesis of cyclopeptides . PyOxim contains Oxyma to reduce racemization .

Individual evidence

  1. ↑ PyOxim data sheet , 98% from Sigma-Aldrich , accessed on October 22, 2016 ( PDF ).
  2. ↑ CA Chantell, MA Onaiyekan, M. Menakuru: Fast conventional Fmoc solid-phase peptide synthesis: a comparative study of different activators. In: Journal of Peptide Science . Volume 18, Number 2, February 2012, pp. 88-91, doi : 10.1002 / psc.1419 , PMID 22147296 .