PyOxime
Structural formula | |||||||
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General | |||||||
Surname | PyOxime | ||||||
other names |
[Ethyl cyano (hydroxyimino) acetato- O 2 ] tri-1-pyrrolidinylphosphonium hexafluorophosphate |
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Molecular formula | C 17 H 29 F 6 N 5 O 3 P 2 | ||||||
External identifiers / databases | |||||||
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properties | |||||||
Molar mass | 527.38 g mol −1 | ||||||
safety instructions | |||||||
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As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . |
PyOxim is a coupling reagent from the group of phosphonium salts. In solid phase peptide synthesis , it reacts faster than PyBOP , but more slowly than COMU , HCTU and HATU, among others . In contrast to HATU and HBTU , it does not lead to chain terminations and is therefore used for the synthesis of cyclopeptides . PyOxim contains Oxyma to reduce racemization .
Individual evidence
- ↑ PyOxim data sheet , 98% from Sigma-Aldrich , accessed on October 22, 2016 ( PDF ).
- ↑ CA Chantell, MA Onaiyekan, M. Menakuru: Fast conventional Fmoc solid-phase peptide synthesis: a comparative study of different activators. In: Journal of Peptide Science . Volume 18, Number 2, February 2012, pp. 88-91, doi : 10.1002 / psc.1419 , PMID 22147296 .