COMU

Structural formula
General
Surname	COMU
other names	(1-Cyano-2-ethoxy-2-oxoethylideneaminooxy) dimethylamino-morpholino-carbenium-hexafluorophosphate
Molecular formula	C 12 H 19 F 6 N 4 O 4 P
External identifiers / databases
EC number	682-899-5
ECHA InfoCard	100.208.431
PubChem	44471148
ChemSpider	26496276
Wikidata	Q20650188
properties
Molar mass	428.27 g mol −1
Physical state	firmly
safety instructions
GHS labeling of hazardous substances	no GHS pictograms
	no GHS pictograms
H and P phrases	H: no H-phrases
	P: no P-phrases
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

COMU [(1-cyano-2-ethoxy-2-oxoethylideneaminooxy) dimethylamino-morpholino-carbenium-hexafluorophosphate] is a coupling reagent which is used in peptide synthesis to generate peptides .

Alternative coupling reagents are e.g. B. HATU , HBTU , HCTU , TBTU , TOMBU and COMBU .

Individual evidence

↑ ^a ^b COMU® data sheet at Sigma-Aldrich , accessed on October 18, 2016 ( PDF ).

↑ R. Subirós-Funosas, L. Nieto-Rodriguez, KJ Jensen, F. Albericio: COMU: scope and limitations of the latest innovation in peptide acyl transfer reagents. In: Journal of Peptide Science . Volume 19, Number 7, July 2013, pp. 408-414, doi : 10.1002 / psc.2517 , PMID 23712932 .

↑ CU Hjørringgaard, A. Brust, PF Alewood: Evaluation of COMU as a coupling reagent for in situ neutralization Boc solid phase peptide synthesis. In: Journal of Peptide Science. Volume 18, Number 3, March 2012, pp. 199-207, doi : 10.1002 / psc.1438 , PMID 22252935 .

↑ YE Jad, SN Khattab, BG de la Torre, T. Govender, HG Kruger, A. El-Faham, F. Albericio: TOMBU and COMBU as Novel Uronium-type peptide coupling reagents derived from Oxyma-B. In: Molecules. Volume 19, number 11, 2014, pp. 18953-18965, doi : 10.3390 / molecules191118953 , PMID 25412042 .

[Sigma-1] COMU® data sheet at Sigma-Aldrich , accessed on October 18, 2016 ( PDF ).

[2] R. Subirós-Funosas, L. Nieto-Rodriguez, KJ Jensen, F. Albericio: COMU: scope and limitations of the latest innovation in peptide acyl transfer reagents. In: Journal of Peptide Science . Volume 19, Number 7, July 2013, pp. 408-414, doi : 10.1002 / psc.2517 , PMID 23712932 .

[3] CU Hjørringgaard, A. Brust, PF Alewood: Evaluation of COMU as a coupling reagent for in situ neutralization Boc solid phase peptide synthesis. In: Journal of Peptide Science. Volume 18, Number 3, March 2012, pp. 199-207, doi : 10.1002 / psc.1438 , PMID 22252935 .

[4] YE Jad, SN Khattab, BG de la Torre, T. Govender, HG Kruger, A. El-Faham, F. Albericio: TOMBU and COMBU as Novel Uronium-type peptide coupling reagents derived from Oxyma-B. In: Molecules. Volume 19, number 11, 2014, pp. 18953-18965, doi : 10.3390 / molecules191118953 , PMID 25412042 .