COMBU

Structural formula
General
Surname	COMBU
Molecular formula	C 13 F 6 H 20 N 5 O 5 P
Brief description	whitish yellow powder
External identifiers / databases
Wikidata	Q27902937
properties
Molar mass	471.30 g mol −1
Physical state	firmly
Melting point	166–167 ° C (decomposition)
safety instructions
GHS hazard labeling ; no classification available
GHS hazard labeling ; no classification available
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

COMBU (4 - {[1,3-Dimethyl-2,4,6-trioxotetrahydropyrimidin-5 (6 H ) ylideneaminooxy] (dimethylamino) methylene} morpholine-4-iumhexafluorophosphate) is a coupling reagent which is used in peptide synthesis to generate peptides is used. It is a derivative of Oxyma -B.

Alternative coupling reagents are e.g. B. HATU , HBTU , HCTU , TBTU , TOMBU and COMU .

Individual evidence

↑ ^a ^b ^c ^d ^e Y. E. Jad, SN Khattab, BG de la Torre, T. Govender, HG Kruger, A. El-Faham, F. Albericio: TOMBU and COMBU as Novel Uronium-type peptide coupling reagents derived from Oxyma-B . In: Molecules. Volume 19, number 11, 2014, pp. 18953-18965, doi : 10.3390 / molecules191118953 , PMID 25412042 .
↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
↑ CU Hjørringgaard, A. Brust, PF Alewood: Evaluation of COMU as a coupling reagent for in situ neutralization Boc solid phase peptide synthesis. In: Journal of Peptide Science. Volume 18, Number 3, March 2012, pp. 199-207, doi : 10.1002 / psc.1438 , PMID 22252935 .

[Jad-1] Y. E. Jad, SN Khattab, BG de la Torre, T. Govender, HG Kruger, A. El-Faham, F. Albericio: TOMBU and COMBU as Novel Uronium-type peptide coupling reagents derived from Oxyma-B . In: Molecules. Volume 19, number 11, 2014, pp. 18953-18965, doi : 10.3390 / molecules191118953 , PMID 25412042 .

[NV-2] This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.

[3] CU Hjørringgaard, A. Brust, PF Alewood: Evaluation of COMU as a coupling reagent for in situ neutralization Boc solid phase peptide synthesis. In: Journal of Peptide Science. Volume 18, Number 3, March 2012, pp. 199-207, doi : 10.1002 / psc.1438 , PMID 22252935 .