Pyrazolam

Structural formula
General
Surname	Pyrazolam
other names	8-Bromo-1-methyl-6- (2-pyridinyl) -4 H - [1,2,4] triazolo [4,3- a ] [1,4] benzodiazepine
Molecular formula	C 16 H 12 BrN 5
External identifiers / databases
PubChem	12562545
Wikidata	Q15409343
properties
Molar mass	354.20 g mol −1
Physical state	firmly
solubility	soluble in organic solvents such as ethanol, DMSO and dimethylformamide
safety instructions
GHS hazard labeling ; no classification available
GHS hazard labeling ; no classification available
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Pyrazolam is a chemical compound belonging to the benzodiazepine group .

Pyrazolam has structural similarities to alprazolam and bromazepam . It is very selective for the α2 and α3 receptor subtypes, which means that it has a strong anti- anxiety effect . It is excreted unchanged in the urine.

Pyrazolam was first synthesized in 1970 by Leo Sternbach's group at Hoffmann-La Roche . Pyrazolam has been used as a research chemical and designer drug since 2012 .

Individual evidence

↑ ^a ^b caymanchem.com: Product Information Pyrazolam , accessed November 10, 2015
↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
↑ JB Hester, P. von Voigtlander: 6-Aryl-4H-s-triazolo [4,3-a] [1,4] benzodiazepines. Influence of 1-substitution on pharmacological activity . In: Journal of Medicinal Chemistry . 22, No. 11, 1979, p. 1390. doi : 10.1021 / jm00197a021 .
↑ ^a ^b Bjoern Moosmann, Laura M. Huppertz, Melanie Hutter, Armin Buchwald, Sascha Ferlaino, Volker Auwärter: Detection and identification of the designer benzodiazepine flubromazepam and preliminary data on its metabolism and pharmacokinetics. In: Journal of Mass Spectrometry. 48, 2013, p. 1150, doi : 10.1002 / jms.3279 .
↑ Bjoern Moosmann, Melanie Hutter, Laura M. Huppertz, Sascha Ferlaino, Lisa Redlingshöfer, Volker Auwärter: Characterization of the designer benzodiazepine pyrazolam and its detectability in human serum and urine. In: Forensic Toxicology. 31, 2013, p. 263, doi : 10.1007 / s11419-013-0187-4 .
↑ M. Łukasik-Głębocka, K. Sommerfeld, A. Teżyk, B. Zielińska-Psuja, P. Panieński, C. Żaba: Flubromazolam - A new life-threatening designer benzodiazepine. In: Clinical toxicology (Philadelphia, Pa.). [electronic publication before printing] November 2015, doi : 10.3109 / 15563650.2015.1112907 , PMID 26585557 .

[caymanchem.com-1] ymanchem.com: Product Information Pyrazolam , accessed November 10, 2015

[NV-2] This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.

[3] JB Hester, P. von Voigtlander: 6-Aryl-4H-s-triazolo [4,3-a] [1,4] benzodiazepines. Influence of 1-substitution on pharmacological activity . In: Journal of Medicinal Chemistry . 22, No. 11, 1979, p. 1390. doi : 10.1021 / jm00197a021 .

[DOI10.1002/jms.3279-4] Bjoern Moosmann, Laura M. Huppertz, Melanie Hutter, Armin Buchwald, Sascha Ferlaino, Volker Auwärter: Detection and identification of the designer benzodiazepine flubromazepam and preliminary data on its metabolism and pharmacokinetics. In: Journal of Mass Spectrometry. 48, 2013, p. 1150, doi : 10.1002 / jms.3279 .

[DOI10.1007/s11419-013-0187-4-5] Bjoern Moosmann, Melanie Hutter, Laura M. Huppertz, Sascha Ferlaino, Lisa Redlingshöfer, Volker Auwärter: Characterization of the designer benzodiazepine pyrazolam and its detectability in human serum and urine. In: Forensic Toxicology. 31, 2013, p. 263, doi : 10.1007 / s11419-013-0187-4 .

[6] M. Łukasik-Głębocka, K. Sommerfeld, A. Teżyk, B. Zielińska-Psuja, P. Panieński, C. Żaba: Flubromazolam - A new life-threatening designer benzodiazepine. In: Clinical toxicology (Philadelphia, Pa.). [electronic publication before printing] November 2015, doi : 10.3109 / 15563650.2015.1112907 , PMID 26585557 .