RNA activation

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The RNA activation (short RNAa ) is a natural mechanism in the cells of mammals and possibly other eukaryotic organisms which one to a paradoxical increase implementation genetic information into a feature leads. The effect of RNA activation is opposite to that of RNA interference and, like this, is based on small RNA molecules such as siRNA and miRNA .

The underlying mechanisms discussed are activation of the transcription of a gene , activation of translation into a protein , interaction with the cell's own miRNA and antisense mechanisms. Promoter- specific interfering RNA molecules can lead to activation of transcription via an activated RNA-induced transcriptional silencing complex . Similarly, a is Argonaute -mediated activation of the translation discussed. Another possible mechanism is a direct interaction with the cell's own miRNA. This mechanism is also used in a targeted manner by so-called antagomirs .

Individual evidence

  1. ↑ Huang V, Qin Y, Wang J, et al. : RNAa is conserved in mammalian cells . In: PLoS ONE . 5, No. 1, 2010, p. E8848. doi : 10.1371 / journal.pone.0008848 . PMID 20107511 . PMC 2809750 (free full text).
  2. ^ Li LC, Okino ST, Zhao H, et al. : Small dsRNAs induce transcriptional activation in human cells . In: Proc. Natl. Acad. Sci. USA . 103, No. 46, November 2006, pp. 17337-42. doi : 10.1073 / pnas.0607015103 . PMID 17085592 . PMC 1859931 (free full text).
  3. ↑ Vasudevan S, Tong Y, Steitz JA : Switching from repression to activation: microRNAs can up-regulate translation . In: Science . 318, No. 5858, December 2007, pp. 1931-4. doi : 10.1126 / science.1149460 . PMID 18048652 .
  4. ^ Krützfeldt J, Rajewsky N, Braich R, et al. : Silencing of microRNAs in vivo with 'antagomirs' . In: Nature . 438, No. 7068, December 2005, pp. 685-689. doi : 10.1038 / nature04303 .