Rainer Liedtke (medical doctor)

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Rainer Kurt Liedtke (born September 16, 1943 in Königsberg ; † September 15, 2012 in Grünwald ) was a German doctor, scientist and entrepreneur. His main focus was the theory and practice of biomedical information systems, medical innovations, new therapies for pain , stress and cell degeneration.

Life

Liedtke graduated from the University of Bonn with a degree in human medicine . For his doctorate at the Institute for Physiological Chemistry at the University of Bonn, he dealt with biochemical studies on DNA and RNA and was a scientific assistant at the Institute for Pharmacology at the University of Bonn. His professional activity includes several years as a hospital doctor (including a women's clinic at the University of Bonn) and research, among other things. a. as a project of the German Research Foundation , after which he held leading positions in the pharmaceutical industry (including director of clinical research at Squibb , medical director at E. Lilly ), was also active as a university lecturer for pharmacology (including the Institute for Pharmacology at the University of Regensburg ), also held guest lectures (pharmacology) a. a. at the University of Frankfurt. He was the founder of several companies (including American Pharmed Labs, now renamed EpiCept) and for several years their Chairman & CEO. Liedtke was a member of several scientific societies in the fields of pharmacology, endocrinology, and biological chemistry.

Inventions and medical developments

These include a. biomedical information systems and a number of new therapies: including transdermal hormonal contraception (1988) and its first clinical evidence (with L. Wildt, University of Erlangen); a bioinformatic concept for the topical transdermal therapy of neuromuscular pain using sodium channel blockers (1993/94) as well as its first clinical proof of effectiveness in back pain and postoperative pain (1995), plus the first market product of this kind in the USA (lidopain). A US market product based on the same concept (Lidoderm) is approved for post-therapeutic pain.

Further developments: Transdermal beta blocker patches and their first clinical evidence of effectiveness in hypertension (with W. Vetter, University of Zurich, H. Vetter, University of Bonn, W. Zidek, University of Münster (1987)) and angina pectoris (1988; with J. Bonelli, F. Gazo, University of Vienna, overview and summarized findings in a special volume 'Drug Research' 1989). Insulin transdermal patch , as an alternative to injections; First evidence preclinical (with K. Suwelack, K. Karzel; University of Bonn (1990)) and clinical in type II diabetics (with M. Sorger, H. Vetter; University of Bonn (1990). Antidepressant effects of the neurohormone oxytocin . Prediction of such effects initially from a new bio-cybernetic model (1998/99), then confirmed experimentally (2000; I. Neumann, University of Regensburg, R. Landgraf, Max Planck Institute, M. Ludwig, University of Edinburgh Model of a cellular pathogenetic mechanism of arteriosclerosis (2006 Current developments. "Intelligent" information systems, new general pain theory Clarification of the mechanism of action of NSAID painkillers and their cause for increased heart attacks and strokes.

Works (selection)

  • Introduction to Drug Therapy. Basics of general pharmacology for medical professionals, dentists and pharmacists. 2nd ext. Ed. G. Fischer, Stuttgart / New York 1985, ISBN 3-437-00425-5 .
  • RK Liedtke (Ed.): Dictionary of drug therapy (clinical pharmacology for physicians and pharmacists). 2nd ext. Ed. G. Fischer, Stuttgart / New York 1985, ISBN 3-437-10959-6 .
  • Rainer K. Liedtke: General Pharmacology . In: D. Adam (Ed.): Handbuch für den Pharmareferenten , Volume 1, 2nd edition. G. Fischer, Stuttgart / New York 1984, ISBN 3-437-00423-9 , pp. 289-345.
  • Critical statements on new biological developments (including genomics, gene food), also in a separate specialist blog blog.newlife-online.de article on drugs and therapy.

Web links

Individual evidence

  1. ↑ APL's progress on pain therapies: Scrip . In: World Pharmaceutical News , Issue No. 2375, October 2, 1998
  2. ↑ Physician introduces pain-relief patch . In: The Sunday Star Ledger , New Jersey, June 4, 1995
  3. ↑ Beta blocker patches: If you have high blood pressure, stick instead of swallowing? In: Therapiewoche 37, 27, 1987, p. 2631
  4. ↑ New TTS: Insulin Patches . In: Apotheker Zeitung No. 48, November 26, 1990
  5. ↑ Happiness hormone comes through the nose . In: Focus , No. 27/2000, p. 130, "Perspektiven"

Individual references to science

  1. ↑ Rainer K. Liedtke (Ed.): Transdermal therapy with the beta blocker Mepindolol. In: Medic. Research / Drug Research. , 39 (II), No. 11a, 1989, ISSN  0004-4172 .
  2. ^ ID Neumann, RK Liedtke, M. Ludwig, R. Langraf: Intranasally applied Oxytocin: Brain uptake and effects on neuronal functions and emotionality summary. In: International Society of PsychoNeuroEndocrinology (ISPNE) XXXI. Annual Meeting 2000, Melbourne.
  3. ↑ CNS: onset of action after minutes. In: Arzneimittelzeitung (AMZ) , No. 11, June 2000.
  4. ^ RK Liedtke, R. Landgraf, ID Neumann: Intranasally applied Oxytocin: A novel route of administration? (Poster), 1st World Congress of Women's Mental Health, Berlin 2001.
  5. ↑ Video introduction to the operational structure of a new and still experimental Internet application for medical self-diagnosis.
  6. ^ Rainer K. Liedtke: A General theory on pain as an integrated thermodynamic mechanism. In: Med Hypotheses. , 2009, 73 (1), pp. 86-89, PMID 19264417
  7. ^ Rainer K. Liedtke: A model on the induction of adverse vascular long-term effects of NSAIDs. In: Journal of Medicinal Chemistry 2009 Jan, 5 (1), pp. 23-28, PMID 19149647
personal data
SURNAME Liedtke, Rainer
ALTERNATIVE NAMES Liedtke, Rainer K .; Liedtke, Rainer Kurt
BRIEF DESCRIPTION German doctor, scientist and entrepreneur
DATE OF BIRTH September 16, 1943
PLACE OF BIRTH Koenigsberg
DATE OF DEATH 15th September 2012
Place of death Grünwald