Ralf P. Brandes
Ralf Peter Louis Brandes (* 1969 ) is a German physiologist at the Johann Wolfgang Goethe University in Frankfurt am Main .
Life
Brandes completed his studies in medicine in 1995 ( Hannover Medical School and Emory University in Atlanta ) and received his doctorate in Hannover in 1996 with the thesis Vascular Superoxide Anion Production: In-Vitro Investigations in Lucigenin-Enhanced Chemiluminescence .
After various positions as a postdoc , Brandes completed his habilitation in 2002 in Frankfurt am Main with the thesis Oxygen Radicals - Signaling Molecules in the Vascular Wall . Since 2006 he has been Professor of Physiology in the Faculty of Medicine at the Johann Wolfgang Goethe University in Frankfurt am Main . Here he has headed the Institute for Cardiovascular Physiology since 2008. Together with the Institute for Vascular Signaling under the direction of Ingrid Fleming , the Institute for Cardiovascular Physiology forms the Vascular Research Center in Frankfurt am Main.
Act
Brandes examined the influence of statins on the function of the inner layer of blood vessels ( endothelium ): they activate NADPH - oxidases , enzymes of the Nox family. He was able to prove that enzymes of this family produce reactive oxygen species - so-called oxygen radicals - which are not harmful under non-pathological conditions, but act as messenger substances . They are involved in the formation of new blood vessels ( angiogenesis ) and mediate the protective effect of erythropoietin .
Brandes' other work deals with the importance of signal transduction of fatty acid products for the development of cardiovascular diseases , with the function of small GTPases and GTPase-activating proteins in signal transduction of the vessels and, in turn, in the development of cardiovascular diseases as well as with the production and action of autacoids .
Awards (selection)
- 1995 Dissertation Prize of the German Society for Angiology
- 2000 Hermann Rein Prize of the German Society for Microcirculation
- 2003 Werner Forßmann Prize from the Ruhr University Bochum
- 2014 Adolf Fick Prize
- 2020 Corresponding member of the North Rhine-Westphalia Academy of Sciences and the Arts
Web links
- Institute for Cardiovascular Physiology at the University Hospital Frankfurt am Main (www.kgu.de)
- Vascular Research Center at the Johann Wolfgang Goethe University Frankfurt am Main (vrc.uni-frankfurt.de)
Individual evidence
- ↑ a b Forßmann Prize awarded to young scientists. Press release from the Ruhr University Bochum (ruhr-uni-bochum.de) from May 15, 2003
- ↑ a b The Frankfurt researcher Prof. Ralf P. Brandes receives the renowned Adolf Fick Prize. Johann Wolfgang Goethe University Frankfurt am Main (uni-frankfurt.de); accessed on May 8, 2014
| personal data | |
|---|---|
| SURNAME | Brandes, Ralf P. |
| ALTERNATIVE NAMES | Brandes, Ralf Peter Louis (full name) |
| BRIEF DESCRIPTION | German physiologist |
| DATE OF BIRTH | 1969 |