Rational design

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Rational design describes the strategy of the targeted design of molecules based on previously gained knowledge. The rational design is often supported by molecular modeling . In contrast to this, directed evolution uses mutation, which occurs at random in some cases, and a subsequent selection .

Examples of rational design are e.g. B. drug design , protein design , vector design , primer design , vaccine design and pathway design .

Individual evidence

  1. ^ Jutta Eichler: Combinatorial Chemistry: Concepts and Strategies (Teubner Study Books Chemistry) , 2003, Vieweg & Teubner. ISBN 978-3519003533 . P. 11.
  2. ↑ CG Noble, PY Shi: Structural biology of dengue virus enzymes: towards rational design of therapeutics. In: Antiviral Research (2012), Vol. 96, No. 2, pp. 115-26. doi : 10.1016 / j.antiviral.2012.09.007 . PMID 22995600 .
  3. ↑ R. Guerois, M. de la Paz: Methods in Molecular Biology, Vol 340:. Protein Design , Humana, New Jersey, 2006. ISBN 1-59745-116-9 .
  4. ^ JA Williams, AE Carnes, CP Hodgson: Plasmid DNA vaccine vector design: impact on efficacy, safety and upstream production. In: Biotechnol Adv. (2009), Volume 27, No. 4, pp. 353-370. doi : 10.1016 / j.biotechadv.2009.02.003 . PMID 19233255 ; PMC 2693335 (free full text).
  5. ↑ C. Rueckert, CA Guzmán: Vaccines: from empirical development to rational design. In: PLoS Pathogens (2012), Volume 8, No. 11, e1003001. doi : 10.1371 / journal.ppat.1003001 . PMID 23144616 ; PMC 3493475 (free full text).
  6. ↑ G. Cambray, VK Mutalik, AP Arkin: Toward rational design of bacterial genomes. In: Curr Opin Microbiol. (2011), Volume 14, No. 5, pp. 624-630. doi : 10.1016 / j.mib.2011.08.001 . PMID 21865081 .