Regenerative Medicine

The Regenerative Medicine (from latin regeneratio , reappearance ' ) is a relatively new field of biomedicine . It deals with the healing of various diseases through the restoration of dysfunctional cells , tissues and organs, both through biological replacement, for example with the help of cultivated tissue, and through the stimulation of the body's own regeneration and repair processes.

application

It is hoped that regenerative medicine will lead to new approaches in the therapy of Parkinson's disease , paraplegia or cancer . But also common diseases such as diabetes mellitus , coronary heart disease or obesity should be cured by regenerative medicine in the future. The lifestyle medicine tries to activate regenerative processes in the body by for an optimal biological environment (diet, physical activity and psychosocial factors) is created.

The principles of regenerative medicine have been used successfully in stem cell transplants for the treatment of leukemia and lymphoma for more than forty years . The medical fields of application of stem cells in regenerative medicine have been increasingly expanded in recent years. Studies show initial success in restoring auditory cells in the inner ear as hearing loss progresses in young children. Great progress has been made in recent years, particularly in organ transplantation . Newer fields of regenerative medicine are so-called tissue engineering (growing tissue and cell associations) and gene therapy (repair or replacement of defective genetic information).

Individual methods

Electrospinning for the production of microfibers from which connective tissue-imitating so-called scaffolds are created
Growth factors and other components of the extracellular matrix that have functions attached to them
Stem cell , Induced pluripotent stem cell in different biological versions, which are administered infused or integrated in scaffolds
Mechanotransduction through the scaffold, which can greatly affect the differentiation of cells
Nanomedical elements various processes based on ultra-small structural elements

literature

Anthony Atala et al. a .: Principles of Regenerative Medicine. 1st edition. Elsevier Academic Press, Amsterdam 2008, ISBN 978-0-12-369410-2 .

Web links

Individual evidence

↑ P. Macchiarini, JC Haag, P. Jungebluth: Regenerative Medicine . In: Journal of Cardiac, Thoracic and Vascular Surgery . tape 29 , no. 3 , June 1, 2015, ISSN 1435-1277 , p. 213-220 , doi : 10.1007 / s00398-014-1094-7 .
↑ J. Jobst: Areas of application of umbilical cord blood donation in regenerative medicine. In: Kigorosa. Roman Safrainer, March 27, 2018, accessed January 6, 2019 .
^ Sujata K. Bhatia: Engineering biomaterials for regenerative medicine: novel technologies for clinical applications . New York 2012, ISBN 978-1-4614-1080-5 .

[1] P. Macchiarini, JC Haag, P. Jungebluth: Regenerative Medicine . In: Journal of Cardiac, Thoracic and Vascular Surgery . tape 29 , no. 3 , June 1, 2015, ISSN 1435-1277 , p. 213-220 , doi : 10.1007 / s00398-014-1094-7 .

[2] J. Jobst: Areas of application of umbilical cord blood donation in regenerative medicine. In: Kigorosa. Roman Safrainer, March 27, 2018, accessed January 6, 2019 .

[3] Sujata K. Bhatia: Engineering biomaterials for regenerative medicine: novel technologies for clinical applications . New York 2012, ISBN 978-1-4614-1080-5 .