Reidun Twarock

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Reidun Twarock (2009)

Reidun Twarock is a German- born mathematical biologist at the University of York . She develops mathematical models for viruses . These are based on higher dimensional grids .

Life

Twarock studied at the University of Cologne and the University of Bath . She finished her studies in 1993 with a Master of Science . She did her doctorate in 1997 at Clausthal University of Technology on quantum mechanical models on the surface of spheres. Then she was a Dorothea Erxleben Fellow at Clausthal University. In 2000 she became a Marie Curie Fellow. In 2001 she became a lecturer in mathematics at the City, University of London . In 2005 she became a reader in mathematics and biology.

In the early 2000s she worked on the Penrose tiling and the surface division of a sphere. In doing so, she developed a model of the surface of the Papovaviridae and thus solved all virology problems for over twenty years . In almost all icosahedral viruses, the proteins of the capsid are arranged in clusters of five and six and comprise a maximum of twelve clusters of five. In contrast, the Papovaviridae, including having cervical cancer caused human papillomaviruses , 72 five clusters. Thus, the protein layout did not correspond to any of the polyhedra known in mathematics . Twarock's model was thus both mathematically and biologically new. It resembled Penrose tiling wrapped around a ball.

These models were found to be useful for studying the assembly and genome of RNA viruses .

Their work is also used in the studies of nanomaterials .

Since 2009 she has been working as a professor of mathematical biology at the University of York.

Honors

It was awarded the IMA gold medal in 2018 .

Individual evidence

  1. ↑ Stewart, Ian. The mathematics of life. Basic Books, 2011.
  2. ↑ Jordana Cepelewicz: The Illuminating Geometry of Viruses. Retrieved July 25, 2019 .
  3. ↑ a b Curriculum Vitae - University of York ( Memento from February 17, 2015 in the Internet Archive )
  4. ↑ R. Twarock, A tiling approach to virus capsid assembly explaining a structural puzzle in virology, Journal of Theoretical Biology, Volume 226, Issue 4, February 21, 2004, pp 477-482, ISSN 0022-5193
  5. ^ Rayment, I., et al. "Polyoma virus capsid structure at 22.5 A resolution." Nature 295.5845 (1982): 110-115.
  6. ^ Mark West: A symmetry approach to viruses . In: Plus Maths . plus magazine. September 30, 2007.
  7. ↑ Keef, Thomas, and Reidun Twarock. "Affine extensions of the icosahedral group with applications to the three-dimensional organization of simple viruses." Journal of mathematical biology 59.3 (2009): 287-313.
  8. ↑ Rolfsson, Óttar, Middleton, Stefani, Manfield, Iain W. et al. (9 more authors) (2016) Direct Evidence for Packaging Signal-Mediated Assembly of Bacteriophage MS2. Journal of Molecular Biology. Pp. 431-448. ISSN 0022-2836
  9. ^ Self-Assembly of Viral Capsids via a Hamiltonian Paths Approach: The Case of Bacteriophage MS2
  10. ↑ R.Twarock, M. Valiunas, & E. Zappa (2015) Orbits of crystallographic embeddings of non-crystallographic groups and applications to virology. Acta Crystallogr. A71, 569-582
  11. ↑ E. Zappa, EC Dykeman & R. Twarock (2014) On the subgroup structure of the group hyperoctahedral in six dimensions, Acta Cryst A 70, 417-428
  12. ↑ Know your onion, Vol 10, p. 244, April 2014
  13. ↑ IMA Gold Medal 2018 awarded to Professor Reidun Twarock. In: IMA. August 14, 2018, Retrieved July 25, 2019 (UK English).
personal data
SURNAME Twarock, Reidun
BRIEF DESCRIPTION German-British mathematical biologist
DATE OF BIRTH 20th century