Relaxin

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Relaxins during pregnancy of vertebrates distributed peptide hormones for the first time in 1926 by Frederick Lee Hisaw described.

In humans, three relaxins are known and four relaxin receptors ( G-protein-coupled receptors ), whereby both relaxin-1 and -2 dock to relaxin receptors 1 and 2, while relaxin-3 and relaxin-3 receptors 1 and 2 belong together. In addition, relaxin-3 is the ligand of relaxin receptor 1.

Relaxin-1 and -2 are formed in women in the decidua cells of the placenta , especially during pregnancy . One effect is the relaxation of the cervix during childbirth by acting on ligaments of the uterus , which widens the birth canal. Relaxin-3 has a potential role in neuropeptide signaling processes. All relaxins have an insulin-like structure: two protein chains are cut out of a precursor and connected to one another via two disulfide bridges .

The determination of the relaxin level is the only hormone determination that can be used to prove pregnancy in domestic dogs . This is possible from the 25th day after ovulation until birth. When sending the blood sample, it should be noted that the hormone is sensitive to light and storage.

gene Size ( AS )
precursor 		Size (AS)
UE1 		Size (AS)
UE2 		End product Size (AS)
end product
RLN1 185 (1-185) 23 (163-185) 31 (23-53) Relaxin-1 54
RLN2 185 (1-185) 24 (162-185) 29 (25-53) Relaxin-2 53
RLN3 142 (1-142) 24 (119-142) 27 (26-52) Relaxin-3 51

See also

literature

  • Lois Jovanovic, Genell J. Subak-Sharpe: Hormones. The medical manual for women. (Original edition: Hormones. The Woman's Answerbook. Atheneum, New York 1987) From the American by Margaret Auer, Kabel, Hamburg 1989, ISBN 3-8225-0100-X , pp. 34 and 385.

Individual evidence

  1. ↑ Science: If a Gopher Can Do It ... , English , accessed February 3, 2011.
  2. ↑ a b UniProt P04808 , UniProt P04090 , UniProt Q8WXF3
  3. ↑ Welsch, Deller: Textbook Histology . Ed .: Welsch. 3. Edition. Elsevier, Munich 2010, ISBN 978-3-437-44431-9 , pp. 445 .
  4. ↑ Axel Wehrend: Key symptoms of gynecology and obstetrics in dogs. Enke Stuttgart 2010, ISBN 978-3-83-041076-8 , p. 60.