Sodium-dependent multivitamin transporter

Sodium-dependent multivitamin transporter
Properties of human protein
Mass / length primary structure	635 amino acids
Secondary to quaternary structure	multipass (13 TMS) membrane protein
Identifier
Gene name	SLC5A6
External IDs	OMIM : 604024 ; UniProt : Q9Y289 ;
Transporter classification
TCDB	2.A.21.5.2
designation	Sodium Symporter Family (SSS)
Occurrence
Homology family	Sodium symporter
Parent taxon	Creature

The sodium-dependent multivitamin transporter (SMVT) ( gene : SLC5A6 ) is the protein in the cell membrane of animal cells that facilitates the introduction of pantothenate , biotin and lipoate . So it is a transport protein . In humans, SMVT occurs in all tissue types, so it is probably also responsible for the absorption of vitamins via the small intestine .

The transport equation is:

Solute (outside) + Na ⁺ (outside) Solute (inside) + Na ⁺ (inside)

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It is a symport with the possible solutes pantothenate , biotin and lipoate . Since SVMT also occurs in the blood-brain barrier , it is a possible target for the pharmaceutical industry to optimize the absorption of drugs in the body.

The regulation of the expression of SVMT carried out at oversupply of biotin by chromatin -Remodeling at the locus of the SLC5A6 - promoter by the Holocarboxysynthetase .

Individual evidence

↑ UniProt Q9Y289
↑ K. Balamurugan, A. Ortiz, HM Said: Biotin uptake by human intestinal and liver epithelial cells: role of the SMVT system. In: American Journal of Physiology-Gastrointestinal and Liver Physiology . 2003; 285: S. G73-G77, doi : 10.1152 / ajpgi.00059.2003 . PMID 12646417 .
↑ TCDB : 2.A.21
↑ S. Luo, VS Kansara, X. Zhu, NK Mandava, D. Pal, AK Mitra: Functional characterization of sodium-dependent multivitamin transporter in MDCK-MDR1 cells and its utilization as a target for drug delivery. In: Molecular Pharmaceutics . Volume 3, Number 3, 2006 May-Jun, pp. 329-339, doi : 10.1021 / mp0500768 . PMID 16749865 . PMC 2553563 (free full text).
↑ M. Gralla, G. Camporeale, J. Zempleni: Holocarboxylase synthetase regulates expression of biotin transporters by chromatin remodeling events at the SMVT locus. In: The Journal of nutritional biochemistry. Volume 19, Number 6, June 2008, pp. 400-408, doi : 10.1016 / j.jnutbio.2007.06.002 . PMID 17904341 . PMC 2396561 (free full text).

Web links

Wikibooks: Biochemistry and Pathobiochemistry: Pantothenate Metabolism - Learning and Teaching Materials

D'Eustachio / reactome.org: Pantothenate transport across the plasma membrane

[1] UniProt Q9Y289

[2] K. Balamurugan, A. Ortiz, HM Said: Biotin uptake by human intestinal and liver epithelial cells: role of the SMVT system. In: American Journal of Physiology-Gastrointestinal and Liver Physiology . 2003; 285: S. G73-G77, doi : 10.1152 / ajpgi.00059.2003 . PMID 12646417 .

[3] TCDB : 2.A.21

[4] S. Luo, VS Kansara, X. Zhu, NK Mandava, D. Pal, AK Mitra: Functional characterization of sodium-dependent multivitamin transporter in MDCK-MDR1 cells and its utilization as a target for drug delivery. In: Molecular Pharmaceutics . Volume 3, Number 3, 2006 May-Jun, pp. 329-339, doi : 10.1021 / mp0500768 . PMID 16749865 . PMC 2553563 (free full text).

[5] M. Gralla, G. Camporeale, J. Zempleni: Holocarboxylase synthetase regulates expression of biotin transporters by chromatin remodeling events at the SMVT locus. In: The Journal of nutritional biochemistry. Volume 19, Number 6, June 2008, pp. 400-408, doi : 10.1016 / j.jnutbio.2007.06.002 . PMID 17904341 . PMC 2396561 (free full text).