Symmetrical dimethylarginine

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Structural formula
Structure of symmetrical dimethylarginine.
General
Surname symmetrical dimethylarginine
other names
  • N , N ′ -dimethylarginine
  • SDMA
Molecular formula C 8 H 18 N 4 O 2
External identifiers / databases
CAS number 30344-00-4
PubChem 169148
ChemSpider 147942
DrugBank DB02302
Wikidata Q23759026
properties
Molar mass 202.25 g mol −1
Physical state

firmly

safety instructions
GHS hazard labeling
no classification available
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Symmetrical dimethylarginine ( SDMA ) is a methylated derivative of the amino acid L - arginine . It arises from the breakdown of proteins ( proteolysis ) in the cell nucleus, gets into the bloodstream and is filtered and excreted by the kidneys. SDMA is an early marker of declining kidney performance in dogs and cats, as it correlates very closely with the glomerular filtration rate and is not dependent on muscle mass like creatinine . With a value> 14 µg / dl in the blood plasma, decreased filtration of the kidneys can be assumed, values ​​between 15 and 19 µg / dl should be checked after two weeks. In cats with chronic kidney disease , the SDMA value rises 17 months earlier than the creatinine value, and in dogs with chronic kidney disease, 10 months earlier.

See also

literature

  • J. Braff, E. Obare, M. Yerramilli, J. Elliott, M. Yerramilli: Relationship between Serum Symmetric Dimethylarginine Concentration and Glomerular Filtration Rate in Cats . In: Journal of Veterinary Internal Medicine . tape 28 , no. 6 , 2014, p. 1699–1701 , doi : 10.1111 / jvim.12446 , PMC 4895615 (free full text).
  • MB Nabity, GE Lees, MM Boggess, M. Yerramilli, E. Obare, M. Yerramilli, A. Rakitin, J. Aguiar, R. Relford: Symmetric Dimethylarginine Assay Validation, Stability, and Evaluation as a Marker for the Early Detection of Chronic Kidney Disease in Dogs . In: Journal of Veterinary Internal Medicine . tape 29 , no. 4 , 2015, p. 1036-1044 , doi : 10.1111 / jvim.12835 , PMC 4895368 (free full text).
  • Stephanie Nather: Early Detection of Kidney Diseases. SDMA as a marker for prevention and monitoring in dogs and cats. In: veterinärspiegel . No. 2 , 2017, p. 47-52 .

Individual evidence

  1. ↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.