Sympatholytic
Sympatholytic , also adrenoceptor antagonists are the substances by blockade of adrenoceptors that excitation transfer from the sympathetic inhibit nerve endings on the sympathetic effector cells.
Sympatholytics can be divided into:
history
Based on Paul Ehrlich's theory, John Newport Langley postulated in 1905 the existence of two different types of receptors in the human body: on the one hand, those with inhibiting and, on the other hand, those with exciting effects. On the basis of various experiments, Henry Hallett Dale was able to confirm the hypothesis a year later. He noticed that the administration of ergot alkaloids weakened the effect of adrenaline . In addition, it was shown that the additional relaxation of the bronchial muscles and the vasodilation persisted. Raymond P. Ahlquist wanted to elucidate this mechanism in 1948 by assuming that there are different receptors on the sympathetically innervated organs of success. He named these as α and β receptors and claimed that these are located on different organs.
Web links
Individual evidence
- ^ Wolf-Dieter Müller-Jahncke , Christoph Friedrich , Ulrich Meyer: Medicinal history . 2., revised. and exp. Ed. Wiss. Verl.-Ges, Stuttgart 2005, ISBN 978-3-8047-2113-5 , pp. 169 .
