Synaptopodine
| Synaptopodine | ||
|---|---|---|
| Properties of human protein | ||
| Mass / length primary structure | 929 amino acids | |
| Isoforms | 3 | |
| Identifier | ||
| Gene names | SYNPO ; KIAA1029 | |
| External IDs | ||
| Occurrence | ||
| Parent taxon | Eukaryotes | |
Synaptopodine is a cytoplasmic actin-associated protein with a molecular mass of approximately 73 kDa . Synaptopodine is found in both the kidney podocytes and the cerebrum .
Occurrence
Synaptopodine is found in the podocytes of the kidney as well as in the brain. In the cerebrum , synaptopodine is expressed in subpopulations of neurons containing spinous processes in the neocortex , hippocampus , striatum and olfactory bulb .
function
The function of synaptopodine was investigated, especially in the brain. There they are essential for the development of the spine apparatus as well as a part of the smooth endoplasmic reticulum on the initial piece of the axon segment . Synaptopodine seems to connect smooth endoplasmic reticulum with the actin cytoskeleton . This is important in processes of synaptic plasticity, especially in the long-term potentiation in some neurons. In the case of podocytes , only the importance of synaptopodine in the formation of stress fibers has been proven.
Individual evidence
- ↑ Peter Mundel, Hans W. Heid, Thomas M. Mundel, Meike Krüger, Jochen Reiser, and Wilhelm Kriz: Synaptopodin: An Actin-associated Protein in Telencephalic Dendrites and Renal Podocytes . In: Journal of Cell Biology . tape 139 , no. 1 , 1997, p. 193-204 , doi : 10.1177 / 1073858409355829 , PMID 9314539 .
- ↑ Thomas Deller, Peter Mundel, Michael Frotscher: Potential Role of Synaptopodin in Spine Motility by Coupling Actin to the Spine Apparatus . In: HIPPOCAMPUS . tape 5 , no. 10 , 2000, pp. 569-581 , PMID 11075827 .
- ^ Menahem Segal, Andreas Vlachos, Eduard Korkotian: The Spine Apparatus, Synaptopodin, and Dendritic Spine Plasticity . In: Neuroscientist . tape 106 , no. 35 , 2010, p. 125-133 , doi : 10.1073 / pnas.0905110106 , PMID 20400711 .
- ↑ Katsuhiko Asanuma, Etsuko Yanagida-Asanuma1, Christian Faul1, Yasuhiko Tomino2, Kwanghee Kim1, Peter Mundel: Synaptopodin orchestrates actin organization and cell motility via regulation of RhoA signaling. In: Nature Cell Biology . tape 8 , no. 5 , 2006, p. 485-493 , doi : 10.1038 / ncb1400 , PMID 16622418 .