Teixobactin
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| Surname | Teixobactin | |||||||||
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N -Methyl-D-phenylalanyl- L -isoleucyl- L -seryl- D -glutaminyl- D -alloisoleucyl- L -isoleucyl- N - [(3 S , 6 S , 9 S , 12 R , 13 S ) -3- [(2 S ) -2-butanyl] -6 - {[(4 S ) -2-imino-4-imidazolidinyl] methyl} -9,13-dimethyl-2,5,8,11-tetraoxo-1-oxa -4,7,10-triazacyclotridecan-12-yl] - L -serinamide |
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| Molecular formula | C 58 H 95 N 15 O 15 | |||||||||
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| Molar mass | 1242.466 g mol −1 | |||||||||
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| As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . | ||||||||||
Teixobactin is an experimental drug with antibiotic properties that was featured in an article in the journal Nature in January 2015 .
properties
The substance teixobactin, which is effective against Gram- positive bacteria, should (so far) not show any development of resistance in those bacteria that are sensitive to teixobactin, because the structure of the bacterial cell wall is interfered with "at many crucial points" and resistance is formed through many simultaneously necessary adaptations of the bacteria is made more difficult. Teixobactin binds to the precursor metabolite of peptidoglycan , lipid II, as well as to the precursor of teichoic acid , lipid III. None of the strains of Staphylococcus aureus or Mycobacterium tuberculosis tested were resistant to teixobactin. Teixobactin was a collaboration between the University of Bonn , the German Center for Infection Research and the Northeastern University with the companies NovoBiotic Pharmaceuticals and Selcia discovered and characterized.
Teixobactin was isolated from the soil-living gram-negative bacterium Eleftheria terrae . Teixobactin is a cyclic depsipeptide that is produced as a non-ribosomal peptide from eleven amino acids by the enzymes Txo1 and Txo2 .
Web links
- Julia Merlot: Dangerous infections: new antibiotic kills resistant germs . In: Spiegel Online , January 8, 2015.
- Kai Kupferschmidt: The pharmacy under your feet . In: Süddeutsche Zeitung , January 8, 2015, p. 18 HBG.
- Joachim Czichos: Teixobactin - a new kind of antibiotic from the soil . In: WISSENSCHAFT aktuell , January 8, 2015.
Individual evidence
- ↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
- ↑ a b c d e LL Ling, T. Schneider, AJ Peoples, AL Spoering, I. Engels, BP Conlon, A. Mueller, TF Schäberle, DE Hughes, S. Epstein, M. Jones, L. Lazarides, VA Steadman , DR Cohen, CR Felix, KA Fetterman, WP Millett, AG Nitti, AM Zullo, C. Chen, K. Lewis: A new antibiotic kills pathogens without detectable resistance. In: Nature. [Electronic publication before printing] January 2015, doi : 10.1038 / nature14098 , PMID 25561178 .