Thomas Bley

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Thomas Bley (born March 1, 1951 in Meißen ) is a German professor of bioprocess engineering .

Life

Thomas Bley studied mathematics at the Technical University of Dresden . From 1975 he worked as a research assistant at the Institute for Biotechnology (IBT) of the Academy of Sciences of the GDR in Leipzig. In 1981 he received his doctorate in the field of biomathematics. In 1990 he successfully completed his habilitation on the subject of "State-structured models in biotechnology - application of delay differential equations to describe the dynamics of microbial populations". In 1994 he moved to the Faculty of Biosciences , Pharmacy and Psychology at the University of Leipzig and took over the management of the Biotechnology Department. From 1996 to 2017 he was full professor for bioprocess engineering at the Institute for Food and Bioprocess Engineering and has been senior professor for bioprocess engineering at the Institute for Natural Materials Technology at the Technical University of Dresden since 2017.

In 2018, Bley received the DECHEMA medal .

Scientific work

During his academic career, Thomas Bley has dealt with the development of mathematical models to describe complex biotechnological cell-reactor systems. These essentially have three goals: They should establish cause-effect relationships between biotic and abiotic parameters, ensure that the process flow is economized and ideally work in real time . In this context, he decisively initiated the application of flow cytometry as a single-cell measurement technique in biotechnology and postulated the bioreactor as an ecosystem, the balance of which is based on the number and type of microorganisms and their individual life cycle. Segregated models based on delay differential equations emerged from this population dynamic approach . You can realistically map biological specifications and combine them with abiotic data and are increasingly being used in dynamic process control strategies in biotechnical processes.

Thomas Bley's scientific work includes over 140 publications, contributions to books and numerous patents. He is a full member of the Saxon Academy of Sciences and the German Academy of Science and Engineering - acatech . He holds leading positions in numerous national scientific organizations and is editor of the Wiley-VCH journal "Engineering in Life Sciences".

The profile of the chair for bioprocess engineering he heads is currently determined by work in the field of white biotechnology . The development of processes for the cultivation of plant cells, phototrophic microorganisms and fungi is becoming more and more important, in which new methods of molecular biomonitoring and the modeling of filamentous (thread-forming) organisms in bioprocesses play an important role.

Publications (selection)

  • with Th. Walther, H. Reinsch, A. Große, K. Ostermann and A. Deutsch: Mathematical modeling of regulatory mechanisms in yeast colony development. In: J. theor. Biol. 229, 2004, pp. 327-338.
  • with M. Fritsch, J. Starruß, A. Loesche and S. Mueller: Cell Cycle Synchronization of Ralstonia eutropha by Continuous Phasing Measured via Flow Cytometry. In: Biotechnology and Bioengineering. 92, 2005, pp. 635-642.
  • with J. Starruß, L. Søgaard-Andersen, and A. Deutsch: A new mechanism for collective migration in Myxococcus xanthus. In: J. Stat. Phys. 128, 2007, pp. 269-286.
  • with J. Ludwig-Müller and MI Georgiev: Metabolite and hormonal status of two types of in vitro hairy root cultures of Devil's claw (Harpagophytum procumbens). In: Process Biochemistry. 43, 2008, pp. 15-23.
  • with S. Noack and W. Klöden: Modeling synchronous growth of bacterial populations in phased cultivation. In: Bioprocess and Biosystems Engineering. 31, 2008, pp. 435-443.
  • with K. Kottmeier, J. Weber, C. Müller and J. Büchs: Asymmetric division of Hansenula polymorpha reflected by a drop of light scatter intensity measured in batch microtiter plate cultivations at phosphate limitation. In: Biotechnology and Bioengineering. 104, No. 3, 2009, pp. 554-561.
  • with S. Müller and H. Harms: Origin and analysis of microbial population heterogeneity in bioprocesses. In: Current Opinion in Biotechnology. 21, No. 1, 2010, pp. 100-113.
  • with S. Müller: Flow Cytometry. In: MC Flickinger (Ed.): Encyclopedia of Industrial Biotechnology, Bioprocess, Bioseparation, and Cell Technology. Volume 4, Wiley, New York 2010, pp. 2451-2467.
  • From single cells to microbial population dynamics: Modeling in biotechnology based on measurements of individual cells. In: Advances in Biochemical Engineering Biotechnology. 124, 2011, pp. 211-227.
  • with VG Georgiev and A. Pavlov: Bioreactors for the Cultivation of Red Beet Hairy Roots. In: Red Beet Biotechnology - Food and Pharmaceutical Applications. Springer, New York 2013, pp. 251-281.
  • with C. Löser, T. Urit and A. Stukert: Formation of ethyl acetate from whey by Kluyveromyces marxianus on a pilot scale. In: Journal of Biotechnology. 163, 2013, pp. 17-23.
  • with K. Wagner, S. Friedrich, C. Stang, N. Schilling, M. Bieda, A. Lasagni and E. Boschke: Initial phases of microbial biofilm formation on opaque, innovative anti-adhesive surfaces using a modular microfluidic system. In : Engineering in Life Sciences. 14, 2014, pp. 76-84.

Web links

Individual evidence

  1. ↑ Senior Professorship in Bioprocess Engineering. Retrieved August 2, 2017 .
  2. ↑ onlinelibrary.wiley.com
personal data
SURNAME Bley, Thomas
BRIEF DESCRIPTION German chemist, biotechnologist
DATE OF BIRTH March 1, 1951
PLACE OF BIRTH Meissen