Thromboxane receptor
| Thromboxane receptor | ||
|---|---|---|
| Properties of human protein | ||
| Mass / length primary structure | 343 amino acids | |
| Secondary to quaternary structure | multipass receptor | |
| Isoforms | 2 | |
| Identifier | ||
| Gene name | TBXA2R | |
| External IDs | ||
| Occurrence | ||
| Parent taxon | Vertebrates | |
The thromboxane receptor (TXA2-R) is a membrane-bound G-protein-coupled receptor in vertebrates that mediates the clumping of platelets in humans . TXA2-R belongs to the group of prostaglandin receptors . Mutations in TBXA2R - gene can hemophilia cause.
When TXA2-R is activated by thromboxane, it causes an increase in intracellular Ca 2+ (Gq-coupled receptor) in connection with inositol triphosphate . This causes:
- In platelets their aggregation .
- In smooth muscle cells their contraction .