Tiagabine

Structural formula
General
Non-proprietary name	Tiagabine
other names	(-) - ( R ) -1- [4,4-Bis (3-methyl-2-thienyl) -but-3-enyl] piperidine-3-carboxylic acid
Molecular formula	C 20 H 25 NO 2 S 2
External identifiers / databases
CAS number 115103-54-3 (tiagabine) 145821-59-6 (tiagabine hydrochloride ) PubChem 60648 DrugBank DB00906 Wikidata Q907219
Drug information
ATC code	N03 AG06
Drug class	Anti-epileptic
properties
Molar mass	375.55 g · mol -1
Physical state	firmly
Melting point	192 ° C (tiagabine hydrochloride )
safety instructions
Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed GHS hazard labeling no classification available
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Tiagabine (trade name Gabitril ^® ) is an antispasmodic drug that is used to treat epilepsy . Chemically, it is a derivative of nipecotic acid .

Mechanism of action

Tiagabine blocks the reuptake of the neurotransmitter gamma-aminobutyric acid (GABA) in nerve cells. This increases its arousal-inhibiting function.

application areas

Tiagabine is used exclusively as add-on therapy for epilepsy with focal and secondary generalized seizures.

Side effects

Depending on the dose, dizziness, tiredness up to drowsiness, headache, tremors, balance disorders, concentration difficulties, mental slowness and nausea occur. Irrespective of the dose, allergic side effects rarely occur with tiagabine. With chronic use, however, in individual cases it can cause what is known as a non-convulsive status epilepticus, a series of small seizures with impaired consciousness without motor expressions.

marketing

Sales in Germany ceased in November 2013. The provider Teva Pharmaceutical Industries gave economic reasons for this.

Individual evidence

1. ^ The Merck Index. An Encyclopaedia of Chemicals, Drugs and Biologicals. 14th edition, 2006, p. 1618, ISBN 978-0-911910-00-1 .
2. ↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
3. ↑ DAZ.online: Gabitril in Germany except for trade from November 22, 2013.

This article is about a health issue. It is not used for self-diagnosis and does not replace a diagnosis by a doctor. Please note the information on health issues !