Transferrin receptor 1

Transferrin receptor 1
other names	T9, p90, CD71, TFRC
	Existing structure data : PDB 1CX8 , PDB 1DE4 , PDB 1SUV
Properties of human protein
Mass / length primary structure	760 amino acids , 84,871 Da
Identifier
External IDs	GeneCards : TFRC ; OMIM : 190010 ; UniProt : P02786 ;
	Orthologue (human)
Entrez	7037
Ensemble	ENSG00000072274
UniProt	P02786
Refseq (mRNA)	NM_001128148.2
Refseq (protein)	NP_001121620.1
PubMed search	7037

The transferrin receptor 1 ( TfR1 ) is a transmembrane transport protein for transferrin in the iron metabolism and is used to smuggle iron ions into a cell via a receptor- mediated endocytosis .

At low concentrations of iron ions, the gene expression of the transferrin receptor is increased via the IRE-BP ( iron response element binding protein ) protein on the iron response element , which means that more iron ions enter the cells.

In addition to TfR1, there is also the transferrin receptor 2 .

use

Since TfR1 is found on many cell types , it was used as a target for receptor-mediated transfection .

literature

U. Testa, L. Kühn, M. Petrini, MT Quaranta, E. Pelosi, C. Peschle: Differential regulation of iron regulatory element-binding protein (s) in cell extracts of activated lymphocytes versus monocytes-macrophages . In: J. Biol. Chem. . 266, No. 21, July 1991, pp. 13925-13930. PMID 1856222 .
TR Daniels, T. Delgado, JA Rodriguez, G. Helguera, ML Penichet: The transferrin receptor part I: Biology and targeting with cytotoxic antibodies for the treatment of cancer . In: Clin. Immunol. . 121, No. 2, November 2006, pp. 144-158. doi : 10.1016 / j.clim.2006.06.010 . PMID 16904380 .
TR Daniels, T. Delgado, G. Helguera, ML Penichet: The transferrin receptor part II: targeted delivery of therapeutic agents into cancer cells . In: Clin. Immunol. . 121, No. 2, November 2006, pp. 159-176. doi : 10.1016 / j.clim.2006.06.006 . PMID 16920030 .

Web links

MeSH transferrin receptor 1
M. Okam: Transerrin and Iron Transport Physiology . In: Information Center for Sickle Cell and Thalassemic Disorders . Brigham and Women's Hospital and Harvard Medical School. January 29, 2001. Retrieved December 19, 2010.

Individual evidence

↑ ZM Qian, H. Li, H. Sun, K. Ho: Targeted drug delivery via the transferrin receptor-mediated endocytosis pathway. In: Pharmacological reviews. Volume 54, Number 4, December 2002, ISSN 0031-6997 , pp. 561-587, PMID 12429868 .
↑ N. Düzgüneş, CT De Ilarduya, S. Simões, RI Zhdanov, K. Konopka, MC Pedroso de Lima: Cationic liposomes for gene delivery: novel cationic lipids and enhancement by proteins and peptides. In: Current medicinal chemistry. Volume 10, Number 14, July 2003, ISSN 0929-8673 , pp. 1213-1220, PMID 12678795 .
↑ U. Lungwitz, M. Breunig, T. Blunk, A. Göpferich: Polyethyleneimine-based non-viral gene delivery systems. In: European journal of pharmaceutics and biopharmaceutics: official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik eV Volume 60, Number 2, July 2005, ISSN 0939-6411 , pp. 247-266, doi : 10.1016 / j.ejpb.2004.11.011 , PMID 15939236 .

[pmid12429868-1] ZM Qian, H. Li, H. Sun, K. Ho: Targeted drug delivery via the transferrin receptor-mediated endocytosis pathway. In: Pharmacological reviews. Volume 54, Number 4, December 2002, ISSN 0031-6997 , pp. 561-587, PMID 12429868 .

[2] N. Düzgüneş, CT De Ilarduya, S. Simões, RI Zhdanov, K. Konopka, MC Pedroso de Lima: Cationic liposomes for gene delivery: novel cationic lipids and enhancement by proteins and peptides. In: Current medicinal chemistry. Volume 10, Number 14, July 2003, ISSN 0929-8673 , pp. 1213-1220, PMID 12678795 .

[3] U. Lungwitz, M. Breunig, T. Blunk, A. Göpferich: Polyethyleneimine-based non-viral gene delivery systems. In: European journal of pharmaceutics and biopharmaceutics: official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik eV Volume 60, Number 2, July 2005, ISSN 0939-6411 , pp. 247-266, doi : 10.1016 / j.ejpb.2004.11.011 , PMID 15939236 .