Trimedoxime bromide

Structural formula
General
Non-proprietary name	Trimedoxime
other names	TMB-4; Dipyroxine; N , N -trimethylene-bis (pyridine-4-aldoxime-dibromide);
Molecular formula	C 15 H 18 Br 2 N 4 O 2
External identifiers / databases
EC number	200-304-5
ECHA InfoCard	100,000,276
PubChem	5359236
Wikidata	Q4463080
Drug information
Drug class	Antidote
properties
Molar mass	446.144 g mol −1
safety instructions
GHS labeling of hazardous substances	no GHS pictograms
	no GHS pictograms
H and P phrases	H: no H-phrases
	P: no P-phrases
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Trimedoxime bromide is an antidote against poisoning with organophosphates .

In a study on rats that were intoxicated with 26 different organophosphates, trimedoxime had the best antidotic effect compared with obidoxime and pralidoxime . An oxime was considered effective if administration prevented death in at least half of the animals. Trimedoxime was found to be ineffective against seven organophosphates ( trichlorfon , Demeton-S-methyl , pyridafenthion , pirimiphos-methyl , azinphosmethyl , dialifos , dimethoate ), while obidoxime was ineffective against ten and pralidoxime against 14.

Individual evidence

↑ Data sheet 1,1′-TRIMETHYLENEBIS (4- (HYDROXYIMINOMETHYL) PYRIDINIUM BROMIDE) from Sigma-Aldrich , accessed on October 29, 2013 ( PDF ).
↑ GA Petroianu, SM Nurulain, N. Nagelkerke, M Shafiullah, J. spot, K. Kuča: Five oximes (K-27, K-48, obidoxime, HI-6 and trimedoxime) in comparison with pralidoxime: survival in rats exposed to methyl-paraoxon . In: Journal of Applied Toxicology . tape 27 , 2007, p. 453–457 , doi : 10.1002 / jat.1224 ( PDF ).
↑ Milan Jokanović, Matej Maksimović: A comparison of trimedoxime, obidoxime, pralidoxime and HI-6 in the treatment of oral organophosphorus insecticide poisoning in the rat . In: Archives of Toxicology . 70, No. 2, December 1995, pp. 119-123. doi : 10.1007 / BF02733672 .

[Sigma-1] Data sheet 1,1′-TRIMETHYLENEBIS (4- (HYDROXYIMINOMETHYL) PYRIDINIUM BROMIDE) from Sigma-Aldrich , accessed on October 29, 2013 ( PDF ).

[2] GA Petroianu, SM Nurulain, N. Nagelkerke, M Shafiullah, J. spot, K. Kuča: Five oximes (K-27, K-48, obidoxime, HI-6 and trimedoxime) in comparison with pralidoxime: survival in rats exposed to methyl-paraoxon . In: Journal of Applied Toxicology . tape 27 , 2007, p. 453–457 , doi : 10.1002 / jat.1224 ( PDF ).

[DOI10.1007/BF02733672-3] Milan Jokanović, Matej Maksimović: A comparison of trimedoxime, obidoxime, pralidoxime and HI-6 in the treatment of oral organophosphorus insecticide poisoning in the rat . In: Archives of Toxicology . 70, No. 2, December 1995, pp. 119-123. doi : 10.1007 / BF02733672 .