Obidoxime chloride
Structural formula | ||||||||||||||||
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Cation (chloride counterions not shown) |
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General | ||||||||||||||||
Non-proprietary name | Obidoxime chloride | |||||||||||||||
other names |
1,1 '- [Oxybis (methylene)] to {4 - [( E ) - (hydroxyimino) methyl] pyridinium} dichloride |
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Molecular formula | C 14 H 16 Cl 2 N 4 O 3 | |||||||||||||||
Brief description |
white solid |
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External identifiers / databases | ||||||||||||||||
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Drug information | ||||||||||||||||
ATC code | ||||||||||||||||
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properties | ||||||||||||||||
Molar mass | 359.21 g · mol -1 (dichloride: C 14 H 16 Cl 2 N 4 O 3 ) | |||||||||||||||
Physical state |
firmly |
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Melting point |
225 ° C (decomposition) |
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safety instructions | ||||||||||||||||
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Toxicological data | ||||||||||||||||
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . |
Obidoxime chloride ( trade name Toxogonin ® from Merck KGaA ) is an antidote against toxins of the phosphoric and phosphonic acid ester type . This can, for a chemical warfare agents such as Sarin his or pesticides used substances such as parathion ( E 605 ). Obidoxime chloride acts as an acetylcholinesterase reactivator when this enzyme is blocked by such acetylcholinesterase inhibitors.
Obidoxime chloride is administered after or during simultaneous administration of atropine . For example, NATO soldiers have auto-injectors available for self-injection into the thigh that contain 2 mg atropine and 220 mg obidoxime chloride and auto-injectors only contain 2 mg atropine. Most of these autoinjectors come from DIL Limited (formerly duphar-interfran Limited ) based in Thane (India).
Isomerism
The dichloride with the empirical formula C 14 H 16 Cl 2 N 4 O 3 exists in two mutually convertible isomeric forms ( syn and anti ) with different melting points:
- 235-236 ° C ( syn form) and
- 218-220 ° C ( anti -form).
Individual evidence
- ↑ a b Data sheet Obidoxime chloride from Sigma-Aldrich , accessed on January 4, 2013 ( PDF ).
- ^ A b c The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals , 14th Edition (Merck & Co., Inc.), Whitehouse Station, NJ, USA, 2006; P. 1166, ISBN 978-0-911910-00-1 .
- ↑ Entry on obidoxime chloride in the ChemIDplus database of the United States National Library of Medicine (NLM) .
- ↑ Acetylcholine Esterase Reactivators , Spektrum.de
- ↑ Development of a modern ABC self-help set for disaster control (Federal Office for Civil Protection and Disaster Aid) ( Memento from January 19, 2017 in the Internet Archive )