Subunit 5 of the Arp 2/3 complex
Subunit 5 of the Arp 2/3 complex | ||
---|---|---|
other names |
p16-ARC |
|
Properties of human protein | ||
Mass / length primary structure | 16.3 kilodaltons / 151 amino acids (isoform 1)
16.6 kilodaltons / 154 amino acids (isoform 2) |
|
Isoforms | 2 | |
Identifier | ||
Gene names | ARPC5 ARC16 | |
External IDs | ||
Orthologue | ||
human | House mouse | |
Entrez | 10092 | 67771 |
Ensemble | ENSG00000162704 | ENSMUSG00000008475 |
UniProt | O15511 | Q9CPW4 |
Refseq (mRNA) | NM_001270439 | NM_026369 |
Refseq (protein) | NP_001257368 | NP_080645 |
Gene locus | Chr 1: 183.63 - 183.64 Mb | Chr 1: 152.77 - 152.78 Mb |
PubMed search | 10092 |
67771
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The subunit 5 of the Arp 2/3 complex , abbreviated p16-ARC or just p16 (because of the molar mass of around 16 kDa) is a structural protein and together with six other proteins forms the Arp 2/3 complex . The protein is encoded by the ARPC5 gene on the first human chromosome .
function
The subunit 5 of the Arp 2/3 complex interacts with the proteins Arp2 , Arp3 , p21 , p20 , p34 and p40 and together with them forms the Arp 2/3 complex, which plays an important role in the formation of actin filaments from G- Actin plays. The complex acts namely as a center for further actin nucleation by an actin dimer mimics the two subunits Arp 2 and 3, but it is more stable than the dimer itself. The exact role of subunit 5 in this complex or other functions of this protein are not yet known.