Subunit A of the fibrin stabilizing factor
| Firbin stabilizing factor, subunit A | ||
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Existing structural data : 1EVU , 1EX0 , 1F13 , 1FIE , 1GGT , 1GGU , 1GGY , 1QRK , 4KTY |
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| Properties of human protein | ||
| Mass / length primary structure | 83 kilodaltons / 732 amino acids | |
| Cofactor | Ca + | |
| Identifier | ||
| Gene names | F13A1 F13A | |
| External IDs | ||
| Enzyme classification | ||
| EC, category | 2.3.2.13 | |
| Response type | Aminoacyl group transfer | |
| Orthologue | ||
| human | House mouse | |
| Entrez | 2162 | 74145 |
| Ensemble | ENSG00000124491 | ENSMUSG00000039109 |
| UniProt | P00488 | Q8BH61 |
| Refseq (mRNA) | NM_000129 | NM_001166391 |
| Refseq (protein) | NP_000120 | NP_001159863 |
| Gene locus | Chr 6: 6.14 - 6.32 Mb | Chr 13: 36.87 - 37.05 Mb |
| PubMed search | 2162 |
74145
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The subunit A of fibrin stabilizing factor is one of two subunits of factor XIII . This factor is activated in the course of blood clotting and consists of two A and two B subunits. While subunit A has an enzymatic function, subunit B has no such function and instead may serve as a carrier molecule in blood plasma.
function
The sub-unit A has two functions:
- On the one hand, it catalyzes the following reaction:
- On the other hand, it links fibronectin to the alpha chains of fibrin .
genetics
The subunit A of the fibrin stabilizing factor is encoded by the 160 kb gene F13A1 by 15 exons . However, five domains that are clearly functional are encoded by separate exons. Mutations in this gene can lead to hereditary factor XIII deficiency .